Electronic Theses and Dissertation

Daun malaka (Phyllanthus emblica) secara empiris telah digunakan sebagai analgesik, hepatoprotektif, anti-piretik, anti-inflamasi, anti-kanker, anti-hiperlipidemia, anti-diare, dan untuk mengobati diabetes. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol daun malaka (Phyllanthus emblica) terhadap nilai hematologi dan gambaran morfologi eritrosit pada mencit jantan (Mus musculus) yang diinduksi streptozotosin (STZ). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan lima perlakuan: P0 (mencit normal sebagai kontrol positif), P1 (mencit anemia yang diinduksi STZ sebagai kontrol negatif), P2 (mencit anemia yang diberi ekstrak etanol daun malaka 300 mg/kg BB), P3 (mencit anemia yang diberi ekstrak etanol daun malaka 600 mg/kg BB), dan P4 (mencit anemia yang diberi ekstrak etanol daun malaka 1200 mg/kg BB). Ekstrak diberikan setiap hari selama 22 hari. Data dianalisis menggunakan ANOVA dan dilanjutkan dengan uji Duncan pada taraf kepercayaan 95%. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol daun malaka berpengaruh signifikan terhadap jumlah eritrosit, hematokrit, dan trombosit. Pemberian pada dosis 1200 mg/kg BB menunjukkan hasil terbaik dalam meningkatkan kadar eritrosit dan trombosit, sementara kadar hemoglobin sedikit meningkat dan leukosit menunjukkan nilai normal setiap perlakuan. Kesimpulan dari penelitian ini adalah ekstrak etanol daun malaka berpotensi sebagai terapi dalam penanganan anemia.

The Malaka leaves (Phyllanthus emblica) are empirically used as an analgesic, hepatoprotective, antipyretic, anti-inflammatory, anticancer, anti-hyperlipidemic, anti-diarrheal, and diabetes management. This study aims to investigate the effect of administering ethanol extract of Malaka leaves (Phyllanthus emblica) on hematological values and erythrocyte morphology in male mice (Mus musculus) induced by streptozotocin (STZ). The research employed a Completely Randomized Design (CRD) with five treatments: P0 (normal mice as the positive control), P1 (STZ-induced anemic mice as the negative control), P2 (anemic mice treated with 300 mg/kg body weight of Malaka leaf extract), P3 (anemic mice treated with 600 mg/kg body weight of Malaka leaf extract), and P4 (anemic mice treated with 1200 mg/kg body weight of Malaka leaf extract). The extract was administered daily for 22 days. Data were analyzed using ANOVA, followed by Duncan's test at a 95% confidence level. The results indicated that the administration of ethanol extract of Malaka leaves had a significant effect on the erythrocyte count, hematocrit, and platelet levels. The dosage of 1200 mg/kg body weight produced the best results in enhancing erythrocyte and platelet counts, while hemoglobin levels showed a slight increase and leukocyte counts remained within normal ranges across all treatments. The conclusion of this study is that ethanol extract of Malaka leaves has the potential to serve as a therapeutic option in the management of anemia.