Electronic Theses and Dissertation

ABSTRAK
Pendahuluan: ST-segment elevation myocardial infarction (STEMI) merupakan manifestasi penyakit jantung koroner akut dengan morbiditas dan mortalitas yang sangat tinggi. Berbagai mekanisme inflamasi berkaitan dengan kejadian STEMI yang melibatkan berbagai penanda inflamasi sistemik seperti leukosit, neutrophil-limphosit ratio (NLR) dan nitrit oksida (NO). Penelitian ini bertujuan untuk menilai korelasi berbagai penanda inflamasi terhadap derajat oklusi arteri koronaria pada penderita STEMI
Metode: Penelitian ini termasuk studi korelatif dengan desain potong lintang yang dilakukan di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh. Derajat berat oklusi arteri koronaria dinilai berdasarkan Skor Synergy between PCI with Taxus and Cardiac Surgery (Syntax). Sampel darah serum penderita STEMI digunakan untuk menilai penanda inflamasi leukosit, NLR dan NO. Analisis Pearson dan Spearman’s correlation test digunakan dengan tingkat kepercayaan 95%.
Hasil: Sebanyak 33 penderita STEMI terlibat dalam penelitian ini dengan distribusi skor Syntax 14 orang (rendah), 13 orang (sedang), dan 5 orang (berat). Penanda inflamasi pada penelitian ini memiliki rerata 12,27 x 103/mm3 (leukosit), 2,84% (NLR) dan 48,22 μM (NO). Skor Syntax dengan rerata 20 (3 – 37) menunjukkan tingkat kemaknaan p > 0,05 terhadap seluruh penanda inflamasi.
Kesimpulan: Tidak terdapat korelasi antara kadar leukosit, NLR dan NO serum dan derajat oklusi arteri koronaria pada penderita STEMI.

Kata kunci: STEMI, derajat oklusi, leukosit, NLR, nitrit oksida

ABSTRACT Introduction: ST-segment elevation myocardial infarction (STEMI) is a manifestation of acute coronary artherial disease with very high morbidity and mortality. Various inflammatory mechanisms are associated with the occurrence of STEMI involving various systemic inflammatory markers such as leukocytes, neutrophil-lymphocyte ratio (NLR) and nitric oxide (NO). This study aimed to assess the correlation of various inflammatory markers to the degree of coronary artery occlusion in STEMI patients. Method: This research is a cross-sectional correlative study conducted at the dr. Zainoel Abidin Banda Aceh general hospital. The severity of coronary artery occlusion was assessed based on the Synergy Score between PCI with Taxus and Cardiac Surgery (Syntax). Serum blood samples from STEMI patients were used to assess inflammatory markers of leukocytes, NLR and NO. Pearson's analysis and Spearman's correlation test were used with a 95% confidence level. Result: A total of 33 STEMI patients were involved in this study with the distribution of Syntax scores of 14 patients (mild), 13 patients (moderate), and 5 people (severe). Inflammation markers in this study had a mean of 12,27 x 103/mm3 (leukosit), 2,84% (NLR) dan 48,22 μM (NO). The average of Syntax score 20 (3 – 37) indicates a significance level of p > 0.05 for all markers of inflammation. Conclusion: There was no correlation between leukocyte, NLR and NO with the degree of coronary artery occlusion in STEMI patients. Keywords: STEMI, occlusion leukocytes, neutrophil-lymphocyte ratio, and nitric oxide