Electronic Theses and Dissertation

Jamur tiram putih (Pleurotus ostreatus (Jacq.) P. Kumm.) memiliki aktivitas antioksidan yang dapat menangkal radikal bebas penyebab terjadinya kerusakan sel dan penuaan dini. Masker gel peel off merupakan salah satu bentuk sediaan kosmetik yang dapat melekat dengan baik di kulit, meningkatkan penetrasi zat aktif, menjaga kelembapan kulit, serta mengangkat sel kulit mati saat dikelupas. Penelitian ini bertujuan untuk membuat formulasi sediaan masker gel peel off dari ekstrak metanol P. ostreatus dan mengetahui hasil evaluasi sediaan yang dihasilkan. Ekstrak yang dihasilkan dikarakterisasi dan dilakukan penapisan fitokimia, diperoleh nilai rendemen 8,24%; kadar air 15,33%; kadar abu total 12,33%; kadar sari larut air 38,33%; dan kadar sari larut etanol 30%; serta terdeteksi mengandung golongan metabolit sekunder alkaloid, tannin, saponin, flavonoid, steroid, dan triterpen. Formulasi sediaan dilakukan dengan menggunakan PVA sebesar 14% dan ekstrak sebesar 0,585%. Sediaan yang dihasilkan (F1) berwarna kuning muda, bentuk gel cairan kental, dan aroma khas eksipien pengharum. Hasil evaluasi menunjukkan pH sediaan sebesar 5,28; viskositas sebesar 15,26 kg/m.s; daya sebar sebesar 7,33 cm; daya lekat sebesar 10,65 detik; dan waktu mengering selama 22,81 menit. Evaluasi setelah cycling test menunjukkan sediaan masih cukup stabil setelah dilakukan enam siklus pengujian. Hasil uji sifat mekanik menunjukkan sediaan dapat menahan kekuatan tarik hingga 3,79 kgf/mm2 dan tidak mudah putus serta dapat meregang dengan elongasi hingga 199,34%. Hasil uji iritasi menunjukkan sediaan tidak menimbulkan tanda-tanda iritasi. Hasil uji kesukaan menunjukkan sediaan cukup disukai untuk parameter bentuk dan warna, serta disukai untuk parameter aroma. Ekstrak metanol P. ostreatus dapat diformulasikan menjadi sediaan masker gel peel off dan menunjukkan hasil evaluasi dalam nilai optimal, kecuali daya sebar yang sedikit melebihi nilai optimal.

White oyster mushroom (Pleurotus ostreatus (Jacq.) P. Kumm.) is known to have antioxidant activity that can counteract free radicals which are one of the causes of cell damage and premature aging. Peel-off gel mask is a cosmetic dosage form that can adhere well to the skin and has the ability to increase the penetration of active ingredients, maintain skin moisture, and remove dead skin cells when exfoliated. This study aims to formulate and evaluate peel-off gel mask preparation from P. ostreatus methanolic extract. The resulting extract was characterized and carried out by phytochemical screening, the yield value was 8.24%; water content was 15.33%; total ash content was 12.33%; water-soluble extractable matter was 38.33%; and ethanol-soluble extractable matter was 30%; and detected to contain secondary metabolites of alkaloids, tannins, saponins, flavonoids, steroids, and triterpenes. The formulation was carried out using 14% PVA and 0.585% extract. The formulation result (F1) is light yellow, with a thick liquid gel form, and has a fragrance excipient aroma. The results of the evaluation showed that the pH was 5.28; viscosity was 15.26 kg/m.s; spreadability was 7.33 cm; adhesion was 10.65 seconds; drying time was 22.81 minutes. Evaluation conducted after the cycling test showed that the formulation remained stable after six test cycles. The results of the mechanical properties test showed that the formulation could withstand a tensile strength of up to 3.79 kgf/mm2 and was not easily broken and could stretch with an elongation of up to 199.34%. The results of the irritation test showed that the preparation did not cause signs of irritation. The results of the preference test showed that the preparation was quite favorable for the dosage form and color parameters, and preferred for the aroma parameters. P. ostreatus methanolic extract can be formulated into a peel-off gel mask preparation and showed the evaluation results in the optimal value, except for the dispersion which slightly exceeds the optimal value.