Electronic Theses and Dissertation

Abstrak

ANALISIS KADAR PROKALSITONIN PADA SEPSIS AKIBAT PNEUMONIA TERHADAP MORTALITAS
DI RSUD dr. ZAINOEL ABIDIN BANDA ACEH

Latar belakang
Procalcitonin/ prokalsitonin (PCT) adalah prohormon kalsitonin yang berperan dalam homeostasis kalsium dan meningkat dengan adanya infeksi bakteri. Kadar PCT yang tinggi pada sepsis dan pneumonia dikaitkan dengan peningkatan risiko kematian. Masih dijumpai perbedaan pendapat dalam mengenai peran PCT sebagai prediktor independen mortalitas pada pasien sepsis.
Tujuan
Untuk mengetahui kadar PCT serum pasien sepsis akibat pneumonia dan untuk mengetahui hubungan kadar PCT serum terhadap mortalitas pada pasien sepsis akibat pneumonia di RSUD dr. Zainoel Abidin Banda Aceh.
Bahan dan Cara
Penelitian ini merupakan penelitian analitik dengan pendekatan retrospektif. 61 orang pasien sepsis akibat pneumonia di RSUDZA Banda Aceh memenuhi kriteria inklusi dan ekslusi dari Januari 2019 sampai Desember 2019. Data dermografi, laboratorium termasuk PCT, dan status mortalitas sampel penelitian dikumpulkan, kemudian dilakukan analisa data.
Hasil
Pasien hidup sebanyak 39 orang (63,93%) dan pasien yang meninggal sebanyak 22 orang (36.07%) dari total 61 pasien penelitian, Kadar PCT berkisar antara 0,51 ng/mL hingga 639,17 ng/mL, Kadar rata-rata PCT sebesar 24,35 ng/mL dengan nilai SD sebesar 84,67 ng/mL. Dijumpai peningkatan angka mortalitas yang berbanding lurus dengan peningkatan kadar PCT pada ketiga kelompok PCT yang tidak bermakna signifikan secara statistik.
Kesimpulan
Dijumpai peningkatan kadar PCT serum rata-rata pasien sepsis akibat pneumonia, Tidak dijumpai hubungan kadar PCT terhadap mortalitas pada pasien sepsis akibat pneumonia.

Kata Kunci : Prokalsitonin , Sepsis, Pneumonia, Mortalitas




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Abstract

ANALYSIS OF PROCALCITONIN LEVELS IN SEPSIS DUE TO PNEUMONIA TOWARDS MORTALITY
IN RSUD dr. ZAINOEL ABIDIN BANDA ACEH

Background
Procalcitonin (PCT) is a calcitonin prohormone that plays a role in calcium homeostasis and increases in bacterial infection. High PCT levels in sepsis and pneumonia are associated with an increased risk of death. There are still differences in understanding regarding the role of PCT as an independent predictor of mortality in septic patients.
Purpose
Purpose of this research is to determine serum PCT levels and to determine the relationship between serum PCT levels and mortality in septic patients due to pneumonia in dr. Zainoel Abidin Banda Aceh.
Method
This study is an analytical study with a retrospective approach. 61 patients sepsis due to pneumonia at RSUDZA Banda Aceh met the inclusion and exclusion criteria from January 2019 to December 2019. Dermographic data, laboratory including PCT and mortality status of the study samples were collected, then data analysis was carried out.
Results
There were 39 living patients (63.93%) and patients who died were 22 people (36.07%) from a total of 61 study patients, PCT levels ranged from 0.51 ng / mL to 639.17 ng/mL, Average levels PCT was 24.35 ng / mL with an SD value about 84.67 ng/mL. There was an increase mortality rate inline which the increase PCT levels in the three PCT groups was not statistically significant.
Conclution
There was an increase serum PCT levels in septic patients due to pneumonia. There was no relationship between PCT levels and mortality in septic patients due to pneumonia.

Keyword : Procalcitonin, Sepsis, Pneumonia, Mortality

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