PENGARUH PROTEKSI VITAMIN E TERHADAP KADAR UREUM DAN KREATININ MENCIT (MUS MUSCULUS) YANG DI PAPAR PLUMBUM | ELECTRONIC THESES AND DISSERTATION

Electronic Theses and Dissertation

Universitas Syiah Kuala

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PENGARUH PROTEKSI VITAMIN E TERHADAP KADAR UREUM DAN KREATININ MENCIT (MUS MUSCULUS) YANG DI PAPAR PLUMBUM


Pengarang

Dimas Arya Umara - Personal Name;

Dosen Pembimbing



Nomor Pokok Mahasiswa

0707101050033

Fakultas & Prodi

Fakultas / / PDDIKTI :

Penerbit

Banda Aceh : Fakultas Kedokteran., 2011

Bahasa

Indonesia

No Classification

613.286

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Plumbum poisoning has become a public health problem in the world.
Vitamin E is an antioxidant compound that allergedly reduces cytotoxity
plumbum. The purpose of this study was to determine the effect of vitamin E in
mice exposed plumbum. This study is a laboratory experimental research which
used a complete random design. In this study, vitamin E was given orally
everyday for 7 days. Then plumbum was given intraperitoneally two hours after
vitamin E. Examination of urea and creatinine was done 2 days after. There were
5 groups in this research, such as: Group I (aquadest), Group II (20 mg /KgBW
plumbum), Group III (200 mg / KgBW Vitamin E + 20 mg / kgBW Plumbum),
Group IV (500 mg / KgBW vitamin E + 20 mg / KgBW plumbum),
Group V (1000 mg / KgBW vitamin E + 20 mg / KgBW plumbum). The results of
this study indicated that there is no significant effect of
vitamin E protection against Plumbum. This may be caused by a lack
of high doses of vitamin E that was given so that the protection that caused
was less effective. The conclusion of this study is vitamin E does not provide
effective protection against plumbum exposure.
Keywords : Plumbum, Vitamin E, Urea and creatine

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