Electronic Theses and Dissertation

ABSTRAK
Peningkatan kadar asam urat dan profil lipid merupakan kelainan mikrovaskular pada pasien diabetes melitus tipe 2. Peningkatan kadar asam urat dapat menyebabkan kelainan lipid. Kelainan lipid juga dapat meningkatkan peningkatan asam urat. Tujuan penelitian ini adalah untuk mengetahui korelasi antara kadar asam urat dengan profil lipid pada pasien diabetes melitus tipe 2. Jenis penelitian ini adalah penelitian analitik observasional dengan rancangan studi potong lintang (cross sectional). Pengambilan data dilakukan pada bulan Oktober-Desember 2015. Pengambilan sampel menggunakan teknik quota sampling sebanyak 35 orang. Data dikumpulkan dengan cara melihat hasil pemeriksaan laboratorium kemudian dianalisis menggunakan uji kolarasi Pearson. Kelompok sampel dengan kadar asam urat yang tinggi didapatkan kadar kolesterol total yang tinggi sebanyak 6 orang, sedangkan yang normal sebanyak 2 orang. Kadar asam urat yang tinggi didapatkan kadar trigliserida yang tinggi sebanyak 5 orang, sedangkan yang normal 3 orang. Kadar asam urat yang tinggi didapatkan kadar LDL yang tinggi sebanyak 5 orang dan yang normal sebanyak 3 orang dan kadar asam urat yang tinggi terdapat kadar HDL yang tinggi sebanyak 6 orang, dan yang memiliki kadar HDL normal sebanyak 2 orang. Terdapat korelasi yang bermakna dengan arah positif terhadap kadar asam urat dengan kadar trigliserida pada pasien diabetes melitus tipe 2 (r=0,413; p=0,014) dan tidak terdapat kolerasi yang signifikan dengan arah positif terhadap kadar asam urat dengan kadar kolesterol total (r=0,192; p=0,269), kadar LDL (r=0,142; p=0,417) dan arah negatif dengan kadar HDL (r= -0,043; p=0,805) pada uji Korelasi Pearson.

Kata kunci: Diabetes Melitus Tipe 2, Kadar Asam Urat, Profil Lipid.














ABSTRACT
Incrased level of uric acid and lipid profile are microvascular abnormalities in patients with diabetes mellitus type 2.. Increased levels of uric acid can cause lipid abnormalities.Lipid abnormalities can make an excess of uric acid in the blood as well. The purpose of this research is to determine the correlation between uric acid levels and lipid profile in patients with diabetes mellitus type 2. This research uses observational analytic studywith cross-sectional study design. Data were collected in October 2015-December 2015. The sampling was using quota sampling as many as 35 people. Data were collected by observing laboratory examination results and subsequently were analyzed by using Pearson’s Correlation Coefficient Test. Group of samples with high uric acid levels obtained high total cholesterol levels as many as 6 people, while who had normal by 2 people. High uric acid levels found high levels of triglycerides as many as 5 people, where as the normal were 3 people. High levels of uric acid obtained high levels of LDL as many as 5 people and the normal were 3 people. High uric acid levels obtained high HDL levels up to 6 people and who had normal HDL levels by 2 people. There is a significant correlation with positive direction of the uric acid levels with triglycerides levels in patients with diabetes mellitus type 2 (r = 0,413; p = 0,014) and there is no significant correlation with positive direction of the uric acid levels with total cholesterol levels (r = 0,192; p = 0,269), LDL levels (r = 0,142; p = 0,417) anda negative direction with the levels of HDL (r = -0,043; p = 0,805) in Pearson Correlation Coefficient Test.

Kata kunci: Diabetes Mellitus Type 2, Uric Acid Levels, Lipid Profile.

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