Electronic Theses and Dissertation

Latar Belakang: Stroke iskemik merupakan penyebab disabilitas neurologis dengan luaran klinis yang bervariasi serta dipengaruhi oleh faktor metabolik seperti indeks trigliserida–glukosa (TyG) dan status gizi. Penelitian mengenai hubungan indeks TyG dan status gizi terhadap luaran klinis stroke iskemik masih terbatas.
Tujuan: Menganalisis hubungan indeks TyG dan status gizi dengan luaran klinis pada pasien stroke iskemik di RSUD dr. Zainoel Abidin Banda Aceh.
Metode: Penelitian observasional analitik dengan desain potong lintang ini melibatkan 90 pasien stroke iskemik pada periode September–November 2025. Indeks TyG dihitung dari kadar trigliserida dan glukosa darah puasa, status gizi dinilai menggunakan indeks massa tubuh, dan luaran klinis diukur dengan Modified Rankin Scale (mRS). Analisis bivariat menggunakan uji Spearman, sedangkan analisis multivariat menggunakan regresi logistik ordinal.
Hasil: Sebagian besar pasien berjenis kelamin laki-laki (62,2%) dan berusia antara 40-59 tahun (45,6%). Indeks TyG tinggi ditemukan pada 56,7% pasien dan obesitas grade I merupakan status gizi terbanyak (34,4%). Analisis bivariat menunjukkan indeks TyG dan status gizi berhubungan signifikan dengan luaran klinis (p < 0,001 dan 0,003). Namun, pada analisis multivariat, indeks TyG tidak menunjukkan hubungan bermakna (p = 0,178). Status gizi normal terbukti sebagai faktor protektif independen terhadap disabilitas pasca-stroke (OR 0,19; 95% CI 0,06–0,56; p = 0,003).
Kesimpulan: Status gizi merupakan determinan prognostik independen yang lebih kuat dibandingkan indeks TyG terhadap luaran klinis pasien stroke iskemik.
Kata kunci: Stroke Iskemik, Indeks Trigliserida-Glukosa, Status Gizi, Luaran Klinis, mRS.

Background: Ischemic stroke is a major cause of neurological disability, with clinical outcomes that vary and are influenced by metabolic factors such as the triglyceride–glucose (TyG) index and nutritional status. However, studies examining the association between the TyG index, nutritional status, and clinical outcomes in ischemic stroke remain limited. Objective: To analyse the association between the TyG index and nutritional status with clinical outcomes in patients with ischemic stroke at RSUD Dr Zainoel Abidin Banda Aceh. Methods: This analytical observational study with a cross-sectional design involved 90 patients with ischemic stroke between September and November 2025. The TyG index was calculated from fasting triglyceride and glucose levels, nutritional status was assessed using body mass index, and clinical outcomes were measured using the Modified Rankin Scale (mRS). Bivariate analyses were performed using the Spearman test, while multivariate analyses were conducted using ordinal logistic regression. Results: Most patients were male (62.2%) and aged 40–59 years (45.6%). A high TyG index was observed in 56.7% of patients, and grade I obesity was the most common nutritional status category (34.4%). Bivariate analysis showed that both the TyG index and nutritional status were significantly associated with clinical outcomes (p < 0.001 and p = 0.003, respectively). However, in multivariate analysis, the TyG index was not significantly associated with clinical outcomes (p = 0.178). Normal nutritional status was identified as an independent protective factor against post-stroke disability (OR 0.19; 95% CI 0.06–0.56; p = 0.003). Conclusion: Nutritional status is a stronger independent prognostic determinant of clinical outcomes in patients with ischemic stroke than the TyG index. Keywords: Ischemic Stroke, Triglyceride–Glucose Index, Nutritional Status, Clinical Outcome, mRS.