Electronic Theses and Dissertation

Latar Belakang: Sirosis hepatis non-viral merupakan penyakit hati kronis progresif yang sering disertai komplikasi sarkopenia, yang berhubungan dengan peningkatan morbiditas dan mortalitas. Interleukin-20 (IL-20), suatu sitokin proinflamasi dari keluarga IL-10, diketahui berperan dalam proses inflamasi dan fibrosis hati. Namun, hubungan antara IL-20 dengan sarkopenia pada sirosis hepatis non-viral belum pernah diteliti.
Tujuan: Mengetahui hubungan kadar IL-20 serum dengan kejadian sarkopenia pada pasien sirosis hepatis non-viral di RSUDZA Banda Aceh.
Metode: Penelitian analitik observasional dengan desain potong lintang dilakukan pada 35 pasien sirosis hepatis non-viral (HBsAg dan anti-HCV negatif). Kadar IL-20 serum diperiksa menggunakan metode ELISA. Penilaian sarkopenia berdasarkan kriteria AWGS 2019 yang meliputi massa otot rangka menggunakan BIA, kekuatan genggam tangan (handgrip strength), dan kecepatan jalan 6 meter. Analisis data menggunakan uji independent samples t-test dengan nilai p < 0,05.
Hasil: Rerata usia subjek adalah 53,29 ± 9,56 tahun dengan dominasi laki-laki (62,9%). Rerata kadar IL-20 serum adalah 38,41 ± 17,31 pg/mL. Sarkopenia ditemukan pada 20 pasien (57,1%), termasuk sarkopenia berat pada 13 pasien (37,1%). Rerata kadar IL-20 secara bermakna lebih tinggi pada kelompok sarkopenia (45,39 ± 16,89 pg/mL) dibandingkan kelompok non-sarkopenia (29,11 ± 13,34 pg/mL) (selisih rerata: 16,28 pg/mL; IK 95%: −27,04 hingga −5,52; t = −3,078; p = 0,004).
Kesimpulan: Peningkatan kadar IL-20 serum berhubungan secara signifikan dengan kejadian sarkopenia pada sirosis hepatis non-viral, sehingga berpotensi sebagai biomarker inflamasi untuk deteksi dini sarkopenia

Background: Non-viral liver cirrhosis is a progressive chronic liver disease frequently complicated by sarcopenia, which is associated with increased morbidity and mortality. Interleukin-20 (IL-20), a pro-inflammatory cytokine of the IL-10 family, has been implicated in hepatic inflammation and fibrosis; however, its relationship with sarcopenia in non-viral liver cirrhosis remains uninvestigated. Objective: To determine the association between serum IL-20 levels and sarcopenia in patients with non-viral liver cirrhosis at RSUDZA Banda Aceh. Methods: An observational analytic study with a cross-sectional design was conducted involving 35 patients with non-viral liver cirrhosis (HBsAg and anti-HCV negative). Serum IL-20 was measured using ELISA. Sarcopenia was assessed using the AWGS 2019 criteria, encompassing skeletal muscle mass (BIA), handgrip strength, and 6-meter walk speed. Data were analyzed using the independent samples t-test (p < 0.05). Results: The mean age was 53.29 ± 9.56 years with male predominance (62.9%). Mean serum IL-20 was 38.41 ± 17.31 pg/mL. Sarcopenia was identified in 20 patients (57.1%), including severe sarcopenia in 13 (37.1%). Mean IL-20 was significantly higher in the sarcopenic group (45.39 ± 16.89 pg/mL) compared to the non-sarcopenic group (29.11 ± 13.34 pg/mL) (mean difference: 16.28 pg/mL; 95% CI: −27.04 to −5.52; t = −3.078; p = 0.004). Conclusion: Elevated serum IL-20 is significantly associated with sarcopenia in non-viral liver cirrhosis, suggesting its potential as an inflammatory biomarker for early sarcopenia detection