Electronic Theses and Dissertation

Diabetes melitus (DM) merupakan penyakit metabolik kronis yang ditandai dengan kadar
glukosa darah tinggi yang melebihi batas normal. Menurut WHO, penyakit ini berkembang
dengan sangat pesat dan mempengaruhi jutaan orang di seluruh dunia. Penelitian ini bertujuan
untuk mengetahui pengaruh ekstrak etil asetat bunga cempaka kuning (Magnolia champaca L.)
terhadap kadar glukosa darah pada mencit yang diinduksi streptozotocin, serta mengidentifikasi
dosis yang paling efektif. Penelitian ini menggunakan desain eksperimental Rancangan Acak
Lengkap dengan 8 perlakuan dan 4 kali pengulangan. Mencit usia 4-5 bulan dengan rata-rata
berat badan (40g) diinduksi streptozotocin dosis 40mg/kgBB. Setelah hewan diabetes,
selanjutnya diberi perlakuan berupa pemberian metformin 500 mg/kgBB (K+) dan pemberian
ekstrak etil asetat bunga cempaka kuning dengan dosis 0 mg/kgBB (K-), 100 mg/kgBB (P1),
200 mg/kgBB (P2), 300 mg/kgBB (P3), 400 mg/kgBB (P4) dan 500 mg/kgBB (P5) kepada
mencit diabetes. Sebagai pembanding digunakan hewan kontrol normal glukosa (K0) tanpa
induksi streptozotocin dan ekstrak etil asetat bunga cempaka kuning. Hasil menunjukkan bahwa
ekstrak etil asetat bunga cempaka kuning mampu menurunkan kadar glukosa darah mencit
secara signifikan. Penurunan kadar glukosa darah puasa paling optimal ditunjukkan pada dosis
400 mg/kgBB.
Kata kunci: bunga, diabetes melitus tipe 2, Magnolia champaca L., streptozotozin

Diabetes mellitus (DM) is a chronic metabolic disease characterizedby blood glucose levels that exceed normal limits. According to the World Health Organization (WHO), this disease is rapidly increasing and affects millions of people worldwide. This study aimed to determine the effect of the ethyl acetate extract of yellow champaca flowers (Magnolia champaca L.) on blood glucose levels in streptozotocin-induced mice and to identify the most effective dose. This study employed an experimental design using a Completely Randomized Design with eight treatments and four replications. Mice aged 4–5 months with an average body weight of (40g) were induced with streptozotocin at a dose of 40 mg/kgBW. After the mice developed diabetes, the treatments consisted of metformin at a dose of 500 mg/kgBW (positive control), ethyl acetate extract of yellow champaca flowers at doses of 0 mg/kgBW (negative control), 100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, 400 mg/kgBW, and 500 mg/kgBW administered to diabetic mice. A normal control group without streptozotocin induction and extract administration was also included for comparison. The results showed that the ethyl acetate extract of yellow champaca flowers significantly reduced blood glucose levels in mice. The most optimal reduction in fasting blood glucose levels was observed at a dose of 400 mg/kgBW Keywords: flowers, Magnolia champaca L., streptozotocin, type 2 diabetes mellitus