Electronic Theses and Dissertation

ABSTRAK

HUBUNGAN FECAL BILE ACID DAN NEUTROPHIL-TO-ALBUMIN RATIO DENGAN ULCERATIVE COLITIS ENDOSCOPIC INDEX OF SEVERITY PADA PASIEN ULCERATIVE COLITIS

Latar Belakang: Ulcerative colitis (UC) merupakan penyakit inflamasi kronis pada kolon yang ditandai dengan peradangan mukosa dan perjalanan penyakit yang kambuh-remisi. Penilaian aktivitas penyakit umumnya dilakukan dengan kolonoskopi menggunakan Ulcerative Colitis Endoscopic Index of Severity (UCEIS), namun prosedur ini bersifat invasif. Oleh karena itu, diperlukan biomarker non-invasif yang dapat mencerminkan tingkat inflamasi mukosa. Perubahan metabolisme fecal bile acid akibat disbiosis mikrobiota usus serta peningkatan neutrophil-to-albumin ratio (NAR) sebagai penanda inflamasi sistemik diduga berkaitan dengan aktivitas penyakit UC.
Tujuan: Menganalisis hubungan fecal bile acid dan NAR terhadap tingkat keparahan penyakit berdasarkan UCEIS pada pasien UC.
Metode: Penelitian ini merupakan studi observasional dengan rancangan potong lintang yang dilakukan pada pasien UC di RSUD dr. Zainoel Abidin Banda Aceh. Data dikumpulkan melalui anamnesis, pemeriksaan klinis, pemeriksaan laboratorium, analisis fecal bile acid dari sampel feses, serta pemeriksaan endoskopi untuk penilaian skor UCEIS. Analisis data dilakukan menggunakan uji univariat, bivariat, dan regresi ordinal.
Hasil: Adanya hubungan signifikan antara kadar deoxycholic acid (DCA) dan lithocholic acid (LCA) dengan UCEIS (P-value

ABSTRACT THE CORRELATION OF FECAL BILE ACID AND NEUTROPHIL-TO-ALBUMIN RATIO WITH ULCERATIVE COLITIS ENDOSCOPIC INDEX OF SEVERITY IN PATIENTS WITH ULCERATIVE COLITIS Background: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon characterized by continuous mucosal inflammation and a relapsing–remitting course. Assessment of disease activity is commonly performed using colonoscopy with the Ulcerative Colitis Endoscopic Index of Severity (UCEIS); however, this procedure is invasive and may cause discomfort for patients. Therefore, non-invasive biomarkers are needed to evaluate disease activity. Alterations in fecal bile acid metabolism due to intestinal dysbiosis and increased neutrophil-to-albumin ratio (NAR) as a marker of systemic inflammation are considered to be associated with UC disease severity. Objective: Analyze the correlation of fecal bile acid and NAR on disease severity based on the UCEIS score in patients with UC. Method: This study used an observational cross-sectional design conducted in patients with ulcerative colitis at Dr. Zainoel Abidin General Hospital, Banda Aceh. Data were collected through clinical evaluation, laboratory examinations, fecal bile acid analysis from stool samples, and colonoscopy to determine the UCEIS score. Statistical analysis included univariate, bivariate, and ordinal regression tests. Results: The results demonstrated a significant correlation of deoxycholic acid (DCA), and lithocholic acid (LCA) levels and UCEIS score (P-value