Electronic Theses and Dissertation

Latar Belakang: Penyakit Jantung Koroner (PJK) merupakan penyebab kematian tertinggi di Indonesia, dengan prevalensi di Provinsi Aceh (1,6%) berada di atas rata-rata nasional. Indeks Aterogenik Plasma (IAP), yang dihitung melalui logaritma rasio Trigliserida terhadap HDL-C, dianggap sebagai indikator kuat keberadaan partikel small dense LDL (sdLDL) yang bersifat sangat pro-aterogenik. Penelitian ini bertujuan untuk menganalisis hubungan antara IAP dengan derajat keparahan stenosis arteri koroner yang dinilai menggunakan Skor Gensini di RSUD dr. Zainoel Abidin, Banda Aceh.
Metode: Penelitian analitik observasional dengan desain potong lintang (cross-sectional) ini melibatkan 93 pasien PJK yang menjalani angiografi koroner pada Juni-Desember 2025. Subjek dipilih menggunakan teknik consecutive sampling. Variabel bebas adalah IAP, sementara variabel terikat adalah Skor Gensini. Analisis data menggunakan uji korelasi Spearman Rank untuk bivariat dan regresi logistik untuk analisis multivariat.
Hasil: Dari 93 responden, mayoritas berusia >55 tahun (52,7%) dan berjenis kelamin laki-laki (77,4%). Sebanyak 63,4% pasien mengalami stenosis berat (>40) dan 46,2% memiliki IAP kategori tinggi (>0,21). Hasil uji bivariat menunjukkan terdapat korelasi positif yang kuat dan signifikan antara IAP dengan Skor Gensini (r = 0,501;p

Background: Coronary Artery Disease (CAD) is the leading cause of death in Indonesia, with the prevalence in Aceh Province (1.6%) exceeding the national average. The Atherogenic Index of Plasma (AIP), calculated as the logarithmic ratio of Triglycerides to HDL-C, is considered a potent indicator of small dense LDL (sdLDL) particles, which are highly pro-atherogenic. This study aims to analyze the correlation between AIP and the severity of coronary artery stenosis as assessed by the Gensini Score at RSUD dr. Zainoel Abidin, Banda Aceh Methods: This observational analytic study with a cross-sectional design involved 93 CAD patients undergoing elective coronary angiography between June and December 2025. Subjects were selected using a consecutive sampling technique. The independent variable was AIP, while the dependent variable was the Gensini Score. Data analysis was performed using the Spearman Rank correlation test for bivariate analysis and logistic regression for multivariate analysis. Results: Among the 93 respondents, the majority were aged >55 years (52.7%) and were male (77.4%). A total of 63.4% of patients presented with severe stenosis (>40), and 46.2% were categorized as having a high AIP (>0.21). Bivariate analysis demonstrated a strong and statistically significant positive correlation between AIP and the Gensini Score (r = 0.501; p < 0.001). Multivariate analysis indicated that AIP was the most dominant independent predictor of stenosis severity (p < 0.001), followed by Diabetes Mellitus (p = 0.008) and lack of physical activity (p = 0.040). Conclusion: There was a moderately strong positive correlation between the Atherogenic Index of Plasma (AIP) and the severity of coronary artery stenosis.