Electronic Theses and Dissertation

Drug Related Problems (DRPs) merupakan permasalahan krusial dalam praktik pelayanan kefarmasian, khususnya pada pasien geriatri yang rentan mengalami komplikasi akibat perubahan fisiologis, komorbiditas, dan polifarmasi. Kejadian DRPs dapat berdampak pada efektivitas terapi, peningkatan lama rawat, serta risiko morbiditas dan mortalitas. Penelitian ini bertujuan untuk mengukur prevalensi DRPs, mengidentifikasi jenis DRPs, serta menganalisis faktor risiko yang berhubungan dengan kejadian DRPs pada pasien geriatri di ruang rawat inap RSUD dr. Zainoel Abidin (RSUDZA). Penelitian ini menggunakan desain observasional analitik dengan pendekatan cross-sectional terhadap 135 lembar PTO pasien geriatri periode Agustus 2024–Agustus 2025. DRPs diklasifikasikan menggunakan PCNE V9.1 dan dianalisis secara univariat, bivariat (Chi-square dan Fisher exact test), serta multivariat (regresi logistik). Hasil menunjukkan prevalensi DRPs sebesar 84,4% (114 pasien) dengan total 210 kejadian. Kategori terbanyak adalah P1.3 (untreated symptoms or indication) 46,7%, diikuti P1.2 (effect of drug treatment not optimal) 28,6%, dan P2.1 (adverse drug reactions) 12,9%. Kategori lainnya meliputi P1.1 dan P3.1 masing-masing 5,71%, serta P3.2 sebesar 0,47%. Analisis multivariat menunjukkan jenis kelamin berhubungan signifikan dengan kejadian DRPs; pasien perempuan memiliki risiko 3,07 kali lebih besar dibandingkan laki-laki (AOR=3,07; 95% CI: 1,11–9,96; p=0,040). Oleh karena itu, diperlukan pemantauan terapi obat yang optimal untuk meningkatkan keamanan dan efektivitas pengobatan.
Kata kunci: Drug Related Problems, geriatri, rawat inap, PCNE V9.1, faktor risiko.

Drug-Related Problems (DRPs) are crucial issues in pharmaceutical practice, especially in geriatric patients who are prone to complications due to physiological changes, comorbidities, and polypharmacy. DRPs can affect the effectiveness of therapy, increase length of stay, and increase the risk of morbidity and mortality. This study aims to measure the prevalence of DRPs, identify the types of DRPs, and analyze the risk factors associated with the occurrence of DRPs in geriatric patients in the inpatient ward of Dr. Zainoel Abidin Regional General Hospital (RSUDZA). This study used an analytical observational design with a cross-sectional approach on 135 PTO sheets of geriatric patients from August 2024 to August 2025. DRPs were classified using PCNE V9.1 and analyzed univariately, bivariately (Chi-square and Fisher exact test), and multivariately (logistic regression). The results showed a DRP prevalence of 84.4% (114 patients) with a total of 210 events. The most common category was P1.3 (untreated symptoms or indication) at 46.7%, followed by P1.2 (effect of drug treatment not optimal) at 28.6%, and P2.1 (adverse drug reactions) at 12.9%. Other categories included P1.1 and P3.1 at 5.71% each, and P3.2 at 0.47%. Multivariate analysis showed that gender was significantly associated with DRPs; female patients had a 3.07 times greater risk than males (AOR=3.07; 95% CI: 1.11–9.96; p=0.040). Therefore, optimal drug therapy monitoring is needed to improve the safety and effectiveness of treatment. Keyword: Drug-Related Problems, geriatrics, inpatient care, PCNE V9.1, risk factor.