NUR ASSYIQIN SAKILA Primary Author mixed material bibliography Banda Aceh Fakultas mipa 2026

Skripsi

ABSTRACT Aripiprazole is an atypical antipsychotic that acts as a partial dopamine and serotonin agonist, commonly used in the treatment of psychotic disorders, particularly schizophrenia. This study aims to evaluate the appropriateness of Aripiprazole use, identify the adverse effects experienced, and analyze the risk factors influencing the occurrence of adverse effects among patients with schizophrenia at Aceh Mental Hospital. This research employed a quantitative descriptive method with a cross-sectional design. A total of 52 respondents who met the inclusion and exclusion criteria were included in the study. Data were collected through interviews, observations, and documentation. Adverse drug reactions experienced by respondents were further analyzed using the Naranjo Algorithm, and medication adherence was measured using the Morisky Medication Adherence Scale 8-item (MMAS-8). Data analysis was conducted using univariate tests, bivariate tests (chi-square test and point-biserial correlation for numerical data), and multivariate logistic regression. The results showed that the use of Aripiprazole was appropriate in terms of the right drug, right dose, right route, and right frequency (100%). The most frequently used dose was 10 mg per day (73.1%), with once-daily administration (100%). The most common adverse effects were tremors (53.8%), dizziness (44.2%), and muscle stiffness (34.6%). Most patients demonstrated high adherence levels (36.5%), followed by moderate (32.7%) and low adherence (30.8%). Factors that significantly influenced the occurrence of side effects included dosage and the timing of symptom onset, with p-values indicating statistical significance (α < 0.05). These findings highlight the importance of routine monitoring and individualized approaches in Aripiprazole therapy to minimize the risk of adverse drug reactions. Keywords: Aripiprazole, adverse drug reaction, schizophrenia, Naranjo, patient adherence. 0 ELECTRONIC THESES AND DISSERTATION Universitas Syiah Kuala 1712607 2026-03-04 21:26:39 2026-03-05 09:53:46 machine generated