Electronic Theses and Dissertation

ABSTRAK
Ultrasonografi grayscale tiroid (UGT) merupakan pemeriksaan penunjang noninvasif dan ekonomis untuk menilai perubahan struktural kelenjar tiroid pada penyakit Graves. Namun, hubungan antara karakteristik gambaran UGT dan durasi minimal maintenance dose therapy (MMDT) belum jelas. Penelitian ini bertujuan untuk menganalisis hubungan antara durasi MMDT dan gambaran ultrasonografi grayscale tiroid pada pasien penyakit Graves. Gambaran ultrasonografi grayscale tiroid diklasifikasikan ke dalam lima pola (A–E). Penelitian ini menggunakan desain cross- sectional dengan analisis bivariat. Hubungan antara durasi MMDT dan gambaran ultrasonografi grayscale tiroid dianalisis menggunakan regresi logistik multinomial, dengan durasi MMDT sebagai variabel kontinu dan gambaran A sebagai kategori referensi. Hasil analisis menunjukkan bahwa durasi MMDT tidak berhubungan secara signifikan dengan gambaran ultrasonografi grayscale tiroid (p > 0,05). Peningkatan durasi MMDT tidak meningkatkan peluang terjadinya gambaran B, C, maupun D dibandingkan gambaran A secara bermakna secara statistik. Penelitian ini menunjukkan bahwa durasi minimum maintenance dose therapy (MMDT) tidak berhubungan dengan gambaran ultrasonografi grayscale tiroid pada pasien penyakit Graves. Variasi gambaran UGT lebih mencerminkan aktivitas autoimun dan perubahan struktural kronik kelenjar tiroid dibandingkan lamanya terapi antitiroid.
Kata kunci: penyakit Graves, ultrasonografi grayscale tiroid, minimum maintenance dose therapy, terapi antitiroid, autoimunitas tiroid.

ABSTRACT Grayscale thyroid ultrasonography (GTU) is a non-invasive and cost-effective modality for assessing structural alterations of the thyroid gland in Graves’ disease. However, the association between GTU patterns and the duration of minimum maintenance dose therapy (MMDT) remains unclear. This study aimed to examine the association between MMDT duration and grayscale thyroid ultrasonographic patterns in patients with Graves’ disease. Grayscale thyroid ultrasonographic findings were classified into five patterns (A–E). A cross-sectional study design with bivariate analysis was applied. The association between MMDT duration and GTU patterns was assessed using multinomial logistic regression, with MMDT modelled as a continuous variable and pattern A as the reference category. The analysis showed no significant association between MMDT duration and grayscale thyroid ultrasonographic patterns (p>0·05). Increasing MMDT duration did not significantly alter the odds of patterns B, C, or D compared with pattern A. This study shows that the duration of minimum maintenance dose therapy (MMDT) is not associated with grayscale thyroid ultrasonographic patterns in patients with Graves’ disease. Variations in GTU patterns are more likely to reflect underlying autoimmune activity and chronic structural changes of the thyroid gland rather than the duration of antithyroid drug maintenance therapy. Keywords: Graves’ disease, grayscale thyroid ultrasonography, minimum maintenance dose therapy, antithyroid therap, thyroid autoimmunity.