Electronic Theses and Dissertation

Tuberkulosis Resisten Obat (TB RO) merupakan tantangan besar dalam pengendalian TB, terutama pada pasien dengan komorbid Diabetes Mellitus Tipe 2 (DMT2) yang dapat mempengaruhi perjalanan penyakit dan respon terapi. Penelitian ini menggunakan desain deskriptif retrospektif dengan data rekam medis pasien TB Paru RO dengan DMT2 di Poliklinik MDR RSUD dr. Zainoel Abidin Banda Aceh pada Oktober 2025 dengan metode total sampling dan jumlah sampel 20 pasien. Hasil penelitian menunjukkan bahwa sebagian besar pasien berusia 45-59 tahun (50%) dan berjenis kelamin laki-laki (60%). Jenis TB Paru RO terbanyak terdiagnosis TB Multidrug Resistance (MDR) (60%). Mayoritas pasien memiliki gejala khas TB Paru (100%), IMT normal (55%), durasi Diabetes Meliuts (DM) < 1 tahun (55%) dan memiliki komorbid hipertensi (10%). Seluruh pasien memiliki kadar HbA1c >8% (100%), dan mayoritas pasien memiliki gambaran radiologi berupa infiltrat (90%), fibrotik (45%), dan kavitas (25%). Mayoritas pasien tidak memiliki kontak dengan pasien TB (65%), memiliki riwayat terapi OAT sebelumnya (60%), pasien menjalani terapi DM jenis terapi kombinasi (70%) dan menjalani pengobatan TB RO regimen BPaL (70%). Temuan ini menunjukkan bahwa karakteristik pasien TB Paru RO dengan komorbid DMT2 didominasi oleh kasus MDR dan gejala klinis khas TB Paru. Penelitian ini memberikan gambaran awal terkait karakteristik pasien TB Paru RO dengan komorbid DMT2 di RSUD dr. Zainoel Abidin Banda Aceh

Kata kunci: TB Resisten Obat, Diabetes Mellitus, TB MDR, Komorbid

Drug Resistant Tuberculosis (DR TB) remains a major challenge in TB control patrticulary among patient with Type 2 Diabetes Mellitus (T2DM), which can influence disease progression and treatment response. This study employed a descriptive retrospective design using medical record data of pulmonary DR TB patients with T2DM at the MDR Clinic of RSUD dr. Zainoel Abidin Banda Aceh in October 2025, utilizing a total sampling method with 20 patients. The results showed that most patients were aged 45–59 years (50%) and male (60%). The most commonly diagnosed type of pulmonary DR TB was Multidrug Resistance (MDR) TB (60%). Most patients presented with typical pulmonary TB symptoms (100%), had a normal Body Mass Index (BMI) (55%), a DM duration of less than 1 year (55%), and a comorbid condition of hypertension (10%). All patients had HbA1c levels >8% (100%), and radiological findings were predominantly infiltrate (90%), fibrosis (45%), and cavitations (25%). The majority had no prior contact with TB cases (65%), had a history of previous TB treatment (60%), received combination therapy for DM (70%), and underwent DR TB treatment with the BPaL regimen (70%). These findings indicate that pulmonary DR TB patients with T2DM were predominantly MDR cases with hypertension as a common comorbidity and presented with typical pulmonary TB symptoms. This study provides an initial overview of the characteristics of pulmonary DR TB patients with T2DM at RSUD dr. Zainoel Abidin Banda Aceh. Keywords: Drug Resistant TB, Type 2 Diabetes Mellitus, MDR TB, Comorbidity