Electronic Theses and Dissertation

Latar belakang: Penyakit paru kronik merupakan penyebab kematian tertinggi ketiga di dunia pada tahun 2019. Aspergilosis paru kronik dapat muncul pada pasien dengan penyakit paru kronik dan berkaitan dengan peningkatan risiko mortalitas dan morbiditas. Diagnosis dini berdasarkan klinis, radiologis dan laboratorium berupa pemeriksaan galactomannan diharapkan dapat membantu diagnosis dini aspergilosis paru kronik.
Tujuan: menganalisa profil klinis dan kadar serum galaktomannan pada pasien penyakit paru kronik dengan risiko aspergilosis paru kronik
Metode: Penelitian analitik observasional dengan desain potong lintang. Sampel penelitian merupakan pasien penyakit paru kronik (PPOK, asma, bekas TB paru dan kanker paru) yang rawat inap di RSUD dr. Zainoel Abidin Banda Aceh pada Februari 2025 - Maret 2025. Data dianalisis dengan SPSS 24 menggunakan Uji spearman dan chi-square.
Hasil: Penelitian ini menunjukkan tidak terdapat hubungan antara profil klinis (batuk berdahak, hemoptoe, sesak napas, fatigue, peurunan berat badan dan indeks massa tubuh) terhadap risiko aspergilosis paru kronik (p >0,05). Gambaran opasitas homogen dan fungus ball berhubungan dengan risiko aspergilosis paru kronik (p=0,001; p=0,000). Kadar galaktomannan berhubungan signifikan terhadap risiko aspergilosis paru kronik (r=0,382; p=0,006). Titik potong kadar galaktomannan yang terbaik dalam memprediksikan risiko aspergilosis paru kronik adalah 47,01 ng/mL dengan sensitivitas 66,7% dan spesifisitas 97,9% (AUC 0,965; p =0,007). Kesimpulan: gambaran foto toraks berupaa opasitas homogen dan fungsu ball serta kadar galaktomannan serum berhubungan signifikan terhadap risiko aspergilosis paru kronik. Peningkatan kadar galaktomannan berhubungan dengan peningkatan kemungkinan risiko aspergilosis paru kronik.
Kata Kunci: penyakit paru kronik, aspergilosis paru kronik, profil klinis, gambaran foto toraks, kadar galaktomannan serum

Background: Chronic lung disease was the third leading cause of death worldwide in 2019. Chronic pulmonary aspergillosis may occur in patients with chronic lung disease and is associated with an increased risk of mortality and morbidity. Early diagnosis based on clinical, radiological, and laboratory findings, including galactomannan testing, is expected to aid in the early diagnosis of chronic pulmonary aspergillosis. Objective: to analyze the clinical profile and serum galactomannan levels in patients with chronic lung disease at risk for chronic pulmonary aspergillosis. Method: Observational analytical research with cross-sectional design. The research sample consists of patients with chronic lung disease (COPD, asthma, post-tuberculosis lung, and lung cancer) who were hospitalized at RSUD dr. Zainoel Abidin Banda Aceh in February 2025 - March 2025. Data were analyzed using SPSS 24 with Spearman test and chi-square. Results: This study shows that there is no relationship between clinical profiles (productive cough, hemoptysis, shortness of breath, fatigue, weight loss, and body mass index) and the risk of chronic pulmonary aspergillosis (p >0.05). The appearance of homogeneous opacities and fungus ball is associated with the risk of chronic pulmonary aspergillosis (p=0.001; p=0.000, respectively). The galactomannan serum is significantly associated with the risk of chronic pulmonary aspergillosis (r=0.382; p=0.006). The optimal cutoff point for galactomannan levels in predicting the risk of chronic pulmonary aspergillosis is 47.01 ng/mL with a sensitivity of 66.7% and specificity of 97.9% (AUC 0.965; p =0.007). Conclusion: Chest Xray characteristic, namely homogeneous opacities and fungus ball, and serum galactomannan levels are significantly related to the risk of chronic pulmonary aspergillosis. An increase in galactomannan levels is associated with an increased likelihood of chronic pulmonary aspergillosis risk. Keywords: Chronic lung disease, Chronic pulmonary aspergillosis, Clinical profile, Chest X-ray image, Serum galactomannan levels.