Electronic Theses and Dissertation

Sindrom Koroner Akut (SKA) merupakan salah satu penyebab utama morbiditas dan mortalitas global. Kadar asam urat diduga berperan dalam mempercepat aterosklerosis melalui mekanisme stres oksidatif, inflamasi kronik dan disfungsi endotel. Penelitian ini bertujuan untuk menganalisis hubungan antara kadar asam urat dan derajat stenosis berdasarkan vessel score angiography pada pasien SKA di RSUD dr. Zainoel Abidin Banda Aceh. Penelitian menggunakan desain observasional cross sectional dengan sampel 100 pasien SKA yang menjalani angiografi pada periode Januari sampai Desember 2024 dan memenuhi kriteria inklusi. Data sekunder diperoleh dari rekam medis meliputi kadar asam urat dan hasil angiografi. Analisis korelasi Spearman digunakan untuk menilai hubungan antara kadar asam urat dan derajat stenosis. Hasil penelitian menunjukkan bahwa 86% subjek berjenis kelamin laki laki dan 54% berada pada kelompok usia 51 sampai 70 tahun. Hiperurisemia ditemukan pada 59% pasien. Derajat stenosis berdasarkan vessel score menunjukkan 60% pasien mengalami 3-vessel disease, 28% mengalami 2-vessel disease dan 12% mengalami 1-vessel disease. Analisis statistik menunjukkan adanya hubungan bermakna antara kadar asam urat dan derajat stenosis (p = 0.033) dengan kekuatan korelasi lemah (r = 0.213). Penelitian ini menyimpulkan bahwa peningkatan kadar asam urat berhubungan dengan peningkatan derajat stenosis pada pasien SKA sehingga kadar asam urat dapat dipertimbangkan sebagai indikator tambahan dalam menilai tingkat keparahan penyakit arteri koroner.

Kata kunci: Asam urat, derajat stenosis, vessel score, angiografi, sindrom koroner akut, aterosklerosis.

Acute Coronary Syndrome (ACS) is one of the leading causes of global morbidity and mortality. Uric acid levels are suspected to contribute to the acceleration of atherosclerosis through mechanisms involving oxidative stress, chronic inflammation, and endothelial dysfunction. This study aims to analyze the relationship between uric acid levels and the degree of stenosis based on vessel score angiography in ACS patients at dr. Zainoel Abidin General Hospital Banda Aceh. This research employed an observational cross sectional design with a sample of 100 ACS patients who underwent angiography between January and December 2024 and met the inclusion criteria. Secondary data were obtained from medical records, including uric acid levels and angiographic findings. Spearman correlation analysis was used to evaluate the relationship between uric acid levels and the degree of stenosis. The results showed that 86% of the subjects were male and 54% were within the 51 to 70 year age group. Hyperuricemia was identified in 59% of patients. Based on the vessel score, 60% of patients had 3-vessel disease, 28% had 2-vessel disease, and 12% had 1-vessel disease. Statistical analysis demonstrated a significant relationship between uric acid levels and the degree of stenosis (p = 0.033) with a weak correlation strength (r = 0.213). This study concludes that increased uric acid levels are associated with a higher degree of stenosis in ACS patients, indicating that uric acid may serve as an additional indicator in assessing the severity of coronary artery disease. Keywords: Uric acid, degree of stenosis, vessel score, angiography, acute coronary syndrome, atherosclerosis.