Electronic Theses and Dissertation

Asma merupakan penyakit inflamasi kronik pada saluran pernapasan yang menyebabkan penyempitan saluran napas dan gejala seperti sesak napas, batuk, dan mengi. Pengobatan asma konvensional sering kali tidak cukup efektif, sehingga terapi alternatif berbasis tanaman, seperti minyak nilam Aceh (Pogostemon cablin Benth), dapat menjadi pilihan yang menjanjikan. Minyak nilam Aceh mengandung senyawa aktif seperi patchouli alkohol, yang memiliki sifat anti inflamasi, antioksidan, dan antibakteri. Penelitian ini bertujuan untuk mengetahui pengaruh terapi minyak nilam Aceh (Pogostemon cablin Benth) terhadap histopatologi paru mencitmodel asma. Penelitian eksperimental dengan rancangan post-test only with control group design. Sampel berupa 24 ekor mencit jantan yang dibagi menjadi 2 kelompok kontrol dan 4 kelompok perlakuan. Kelompok kontrol negatif diberikan aquades dan kelompok kontrol positif diberikan ovalbumin, sedangkan kelompok perlakuan diberikan dexamethasone 5 mg/kgBB, minyak nilam Aceh 0,25μL, 0,5μL, dan 1μL. sedian uji diberikan secara oral pada dexametason dan nebul pada minyak nilam. Hasil penelitian untuk rata-rata histopatologi paru kemudian dianalisis menggunakan uji Anova didapatkan 0,013, diperoleh hasil memiliki perbedaan bermakna. Kata kunci: Minyak nilam Aceh (Pogostemon cablin Benth),histopatologi paru, mencit, asma, patchouli alkohol

Asthma is a chronic inflammatory disease of the respiratory tract that causes airway narrowing and symptoms such as shortness of breath, cough, and wheezing. Conventional asthma treatments are often not sufficiently effective, making alternative therapies based on plants, such as Aceh patchouli oil (Pogostemon cablin Benth), a promising option. Aceh patchouli oil contains active compounds such as patchouli alcohol, which has anti-inflammatory, antioxidant, and antibacterial properties. This study aims to investigate the effect of Aceh patchouli oil (Pogostemon cablin Benth) on the lung histopathology of asthma model mice. An experimental study with a post-test only with control group design was conducted. The sample consisted of 24 male mice, divided into 2 control groups and 4 treatment groups. The negative control group was given aquadest, and the positive control group was given ovalbumin, while the treatment groups were given dexamethasone 5 mg/kgBW, Aceh patchouli oil 0.25μL, 0.5μL, and 1μL. The test preparations were administered orally for dexamethasone and nebulized for patchouli oil. The average lung histopathology results were analyzed using ANOVA, yielding a p-value of 0.013, which indicates a significant difference.Keyword: Pogostemon cablin Benth, histopathologic images, mice, asthma, patchouli alcohol