Electronic Theses and Dissertation

Osteoartritis (OA) lutut merupakan penyakit sendi degeneratif yang sering dijumpai pada usia lanjut, ditandai dengan kerusakan kartilago dan keterbatasan fungsi sendi. Platelet-Rich Plasma (PRP) kini banyak diteliti sebagai terapi regeneratif non-bedah. Penelitian ini bertujuan mengevaluasi efektivitas PRP pada pasien OA lutut berdasarkan skor Numerical Rating Scale (NRS) dan WOMAC. Desain penelitian adalah analitik observasional retrospektif dengan sampel 30 pasien OA lutut yang mendapat enam kali injeksi PRP. Penilaian dilakukan pada bulan ke-0, 2, 6, dan 12. Hasil menunjukkan penurunan signifikan skor NRS dari 8,23 menjadi 2,63, serta WOMAC dari 64,87 menjadi 32,70 pada bulan ke-12 (p < 0,05). Disimpulkan bahwa PRP efektif mengurangi nyeri dan memperbaiki fungsi sendi, sehingga dapat dipertimbangkan sebagai terapi alternatif non-bedah pada pasien OA lutut.
Kata kunci: Osteoartritis lutut, Platelet-Rich Plasma, NRS, WOMAC

Knee osteoarthritis (OA) is a common degenerative joint disease in the elderly, characterized by cartilage damage and limited joint function. Platelet-Rich Plasma (PRP) has recently been investigated as a regenerative non-surgical therapy. This study aimed to evaluate the effectiveness of PRP in patients with knee OA using the Numerical Rating Scale (NRS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The study employed an observational analytic retrospective design with a sample of 30 knee OA patients who received six PRP injections. Assessments were conducted at months 0, 2, 6, and 12. The results showed a significant reduction in NRS scores from 8.23 to 2.63, as well as a decrease in WOMAC scores from 64.87 to 32.70 at month 12 (p < 0.05). In conclusion, PRP was proven effective in reducing pain and improving joint function, and therefore can be considered a safe non-surgical alternative therapy for patients with knee OA. Keywords: Knee Osteoarthritis, Platelet-Rich Plasma, NRS, WOMAC