Electronic Theses and Dissertation

Apendisitis akut merupakan salah satu penyebab tersering dari kasus gawat darurat abdomen yang membutuhkan tindakan bedah segera. Penundaan diagnosis dapat menyebabkan komplikasi serius seperti perforasi, peritonitis, dan abses. Pemeriksaan hematologis sederhana seperti Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), dan Monocyte-to-Lymphocyte Ratio (MLR) dapat digunakan sebagai indikator inflamasi sistemik yang berpotensi membantu membedakan apendisitis akut dengan komplikasi dan tanpa komplikasi. Penelitian ini bertujuan untuk menganalisis perbedaan nilai NLR, PLR, dan MLR antara pasien apendisitis akut dengan komplikasi dan tanpa komplikasi, serta menilai kemampuan diagnostik masing-masing indeks melalui nilai Area Under the Curve (AUC), sensitivitas, spesifisitas, dan nilai cut-off optimal. Penelitian ini merupakan studi observasional analitik dengan desain komparatif menggunakan data rekam medis pasien apendisitis akut yang menjalani tindakan apendektomi di RSUD dr. Zainoel Abidin Banda Aceh periode Januari 2023–Desember 2024. Sebanyak 77 Pasien memenuhi kriteria inklusi, terdiri dari 38 (49.35%) Pasien apendisitis akut dengan komplikasi dan 39 (50.65%) pasien tanpa komplikasi. Hasil penelitian menunjukkan adanya perbedaan bermakna NLR (P-value 0,003), PLR (P-value

Acute appendicitis is one of the most common causes of abdominal emergencies requiring prompt surgical intervention. Delayed diagnosis can lead to serious complications such as perforation, peritonitis, and abscess formation. Simple hematological examinations such as the Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Monocyte-to-Lymphocyte Ratio (MLR) have been widely studied as indicators of systemic inflammation that may help differentiate between complicated and non-complicated appendicitis. This study aimed to analyze the differences in NLR, PLR, and MLR values between patients with complicated and non-complicated acute appendicitis and to evaluate the diagnostic performance of each index based on the Area Under the Curve (AUC), sensitivity, specificity, and optimal cut-off values. This was an analytical observational study with a comparative design using medical record data of patients with acute appendicitis who underwent appendectomy at dr. Zainoel Abidin General Hospital, Banda Aceh, from January 2023 to December 2024. A total of 77 patients met the inclusion criteria, consisting of 38 (49.35%) patients with complicated appendicitis and 39 (50.65%) with non-complicated appendicitis. The results showed significant differences in NLR (P-value 0.003), PLR (P-value