Electronic Theses and Dissertation

Osteoarthritis (OA) lutut merupakan penyakit sendi degeneratif yang menyebabkan nyeri kronis, keterbatasan gerak, dan penurunan Quality of Life. Terapi Platelet-Rich Plasma (PRP) mengandung faktor pertumbuhan yang berperan dalam regenerasi jaringan dan perbaikan fungsi sendi, sehingga berpotensi meningkatkan QoL pasien OA lutut. Penelitian ini bertujuan mengevaluasi pengaruh terapi PRP terhadap perubahan skor QoL pasien OA lutut. Desain penelitian analitik observasional dengan pendekatan retrospektif cross sectional dilakukan pada pasien OA lutut yang telah menjalani terapi PRP di Klinik Prof. Dr. dr. Dessy R. Emril, Sp.S(K). Pengukuran QoL menggunakan kuesioner WHOQoL-BREF mencakup empat domain: fisik, psikologis, hubungan sosial, dan lingkungan, dengan perbandingan skor sebelum terapi, 2 bulan, 6 bulan, dan 1 tahun setelah terapi. Analisis data menggunakan Repeated Measures ANOVA dan uji T berpasangan. Hasil menunjukkan peningkatan signifikan pada seluruh domain QoL (p < 0,05), dengan peningkatan tertinggi pada domain psikologis. Kesimpulannya, terapi PRP berpengaruh positif terhadap peningkatan QoL pasien OA lutut dan dapat menjadi alternatif terapi yang efektif untuk memperbaiki fungsi sendi serta kesejahteraan pasien.

Knee osteoarthritis (OA) is a degenerative joint disease that causes chronic pain, limited mobility, and decreased quality of life (QoL). Platelet-Rich Plasma (PRP) therapy contains growth factors that play a role in tissue regeneration and joint function improvement, thereby potentially enhancing the QoL of patients with knee OA. This study aimed to evaluate the effect of PRP therapy on changes in QoL scores among knee OA patients. An analytical observational study with a retrospective cross-sectional design was conducted on patients with knee OA who underwent PRP therapy at the Clinic of Prof. Dr. Dessy R. Emril, Sp.S(K). QoL was measured using the WHOQoL-BREF questionnaire, which includes four domains: physical, psychological, social relationships, and environmental, comparing scores before therapy, and at 2 months, 6 months, and 1 year after therapy. Data were analyzed using Repeated Measures ANOVA and paired t-tests. The results showed a significant improvement in all QoL domains (p < 0.05), with the highest increase observed in the psychological domain. In conclusion, PRP therapy has a positive effect on improving the QoL of knee OA patients and can be an effective alternative therapy to enhance joint function and overall well-being.