Electronic Theses and Dissertation

Kecombrang (Etlingera elatior (Jack.), tanaman dari famili Zingiberaceae, dikenal mengandung senyawa bioaktif seperti flavonoid, saponin, dan tanin yang berpotensi sebagai agen antikanker. Penelitian ini bertujuan untuk mengevaluasi potensi ekstrak etanol daun E. elatior dalam menghambat perkembangan kanker payudara secara in vivo pada mencit betina (Mus musculus L.) yang diinduksi dengan senyawa karsinogenik 7,12-Dimetilbenz(α)Anthracene (DMBA). Rancangan yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan enam kelompok perlakuan, yaitu kontrol, kontrol negatif (DMBA), serta perlakuan dengan dosis ekstrak etanol E. elatior 125 mg/KgBB, 250 mg/KgBB, 500 mg/KgBB, dan 1000 mg/KgBB. Parameter yang diamati meliputi perubahan fisik mencit, gejala klinis, dan mortalitas mencit akibat paparan DMBA. Hasil menunjukkan bahwa ekstrak dosis 500 mg/KgBB paling efektif dalam mempertahankan berat badan dan menekan gejala toksisitas. Secara klinis, mencit yang terpapar DMBA mengalami peningkatan agresivitas, penurunan kemampuan motorik, kerontokan rambut, dan perubahan warna feses. Sementara itu, data mortalitas menunjukkan bahwa peningkatan dosis DMBA terhadap mencit secara signifikan menurunkan ketahanan terhadap efek toksik DMBA. Kesimpulannya, ekstrak etanol daun E. elatior menunjukkan potensi sebagai agen antikanker payudara

Kecombrang (Etlingera elatior (Jack.)), a plant from the Zingiberaceae family, is known to contain bioactive compounds such as flavonoids, saponins, and tannins that have potential as anticancer agents. This study aims to evaluate the potential of ethanolic extract of E. elatior leaves in inhibiting breast cancer development in vivo in female mice (Mus musculus L.) induced with the carcinogenic compound 7,12-Dimethylbenz(α)Anthracene (DMBA). The experimental design used was a Completely Randomized Design (CRD) with six treatment groups: control, negative control (DMBA), and treatments with E. elatior ethanolic extract at doses of 125 mg/KgBB, 250 mg/KgBB, 500 mg/KgBB, and 1000 mg/KgBB. The observed parameters included physical changes in the mice, clinical symptoms, and mortality due to DMBA exposure. The results showed that the 500 mg/KgBB dose of extract was the most effective in maintaining body weight and suppressing signs of toxicity. Clinically, DMBA-exposed mice exhibited increased aggressiveness, decreased motor ability, hair loss, and changes in fecal color. Meanwhile, mortality data indicated that increasing DMBA doses significantly reduced resistance to its toxic effects. In conclusion, the ethanolic extract of E. elatior leaves demonstrates potential as a breast cancer chemopreventive agent.