Electronic Theses and Dissertation

Pemanfaatan tanaman herbal dari famili Zingiberaceae, termasuk Hornstedtia conoidea Ridl., secara tradisional telah dikenal memiliki potensi sebagai agen terapeutik. Namun, data ilmiah mengenai efek biologis spesifiknya, khususnya terhadap organ hati, masih terbatas. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak metanol daun Hornstedtia conoidea Ridl. (EMDHC) terhadap kondisi klinis, perubahan berat dan warna organ hati, dan gambaran histopatologis hati tikus putih jantan (Rattus norvegicus Berkenhout.) yang diinduksi streptozotocin. Penelitian ini menggunakan metode eksperimental dengan Rancangan Acak Lengkap (RAL) yang terdiri dari 6 kelompok perlakuan dan 4 ulangan. Kelompok perlakuan meliputi: kontrol normal (K0), kontrol negatif (K-; hanya diinduksi streptozotocin), kontrol positif (K+; diinduksi streptozotocin dan diberikan glibenklamid), serta tiga kelompok perlakuan yang diberikan EMDHC dengan dosis (P1) 125 mg/KgBB, (P2) 250 mg/KgBB, dan (P3) 500 mg/KgBB yang diberikan secara oral. Hasil penelitian menunjukkan bahwa kelompok K- mengalami penurunan berat badan, perubahan warna hati yang signifikan, dan tingkat kerusakan histologis hati yang tinggi berupa nekrosis dan degenerasi. Sebaliknya, kelompok perlakuan K+, P2 dan P3 menunjukkan perbaikan kondisi klinis serta penurunan tingkat nekrosis dan degenerasi, terutama pada kelompok P3 yang mendekati kondisi kontrol normal. Pemberian EMDHC diduga memberikan efek protektif terhadap jaringan hati.

The use of herbal plants from the Zingiberaceae family, including Hornstedtia conoidea Ridl., has traditionally been known to have potential as therapeutic agents. However, scientific data regarding its specific biological effects, especially on the liver, is still limited. This study aims to determine the effect of administering methanol extract of Hornstedtia conoidea Ridl. leaves on clinical conditions, changes in liver weight and color, and histopathological appearance of the liver of male white rats (Rattus norvegicus Berkenhout.) induced by streptozotocin. This study used an experimental method with a Completely Randomized Design (CRD) consisting of 6 treatment groups and 4 replications. The treatment groups included: normal control (K0), negative control (K-; only streptozotocin induced), positive control (K+; streptozotocin induced and given glibenclamide), and three treatment groups given methanol extract of Hornstedtia conoidea Ridl. leaves at doses (P1) 125 mg/KgW, (P2) 250 mg/KgW, and (P3) 500 mg/KgW administered orally. The results showed that the K- group experienced weight loss, significant liver discoloration, and high levels of histological liver damage in the form of necrosis and degeneration. In contrast, the K+, P2 and P3 treatment groups showed improvements in clinical conditions and decreased levels of necrosis and degeneration, especially in the P3 group which approached normal control conditions. The administration of methanol extract of Hornstedtia conoidea Ridl. leaves is thought to have a protective effect on liver tissue.