Electronic Theses and Dissertation

Latar Belakang: Kanker paru adalah penyebab utama kematian terkait kanker di seluruh dunia. Diagnosis dini adalah pilihan yang baik dalam mengurangi jumlah kematian akibat kanker paru. Teknik biopsi yang tepat dapat membantu meningkatkan angka deteksi dini kanker paru.
Tujuan: Untuk mengetahui perbandingan sensitivitas dan spesifisitas menggunakan gun biopsy dibandingkan dengan TTNA.
Metode: Penelitian analitik obervasional dengan desain potong lintang. Pengambilan data diambil secara bersamaan (point time approach), Sampel penelitian diambil berdasarkan teknik total sampling pada 30 pasien dengan diagnosis kerja kanker paru yang dirawat di RSUD dr. Zainoel Abidin Banda Aceh pada September 2024 hingga Desember 2024.
Hasil: Penelitian ini menunjukkan bahwa Gun Biopsi merupakan modalitas yang lebih unggul dibanding dengan Transthoracic Needle Aspiration dengan nilai AUC sebesar 0,833, akurasi 76,3%, sensitivitas 66,7%, spesifisitas 100,0%, Positive Predictive Value (PPV) 100,0% dan Negative Predictive Value (NPV) sebesar 56,3%. TTNA menunjukkan nilau AUC 0,762, akurasi 66,7, sensitivitas 52,4%, spesifisitas 100,0%, PPV 100,0% dan NPV sebesar 47,4%. Tidak ada perbedaan hasil jenis sel berdasarkan pemeriksaan patologi anatomi antar kedua teknik pengambilan sampel.
Diskusi: Pengambilan sampel menggunakan gun biopsy dapat meningkatkan tingkat deteksi dari kanker paru. Tidak adanya perbedaan signifikan jenis sel sampel pada penelitian ini dikarenakan sampel diambil dari pasien yang sama.
Kata Kunci: Kanker Paru, Teknik biopsi, Gun Biopsy, Transthoracic Needle Aspiration

Background: Lung cancer is the leading cause of cancer-related deaths worldwide. Early diagnosis is a good option in reducing the number of deaths from lung cancer. Appropriate biopsy techniques can help increase early detection rates of lung cancer. Objective: To determine the comparison of diagnostic accuracy, sensitivity and specificity examination gun biopsy compared to Transthoracic Needle Aspiration. Method: Observational analytical research with a cross-sectional design. Data collection is taken simultaneously (point time approach), The research sample was taken based on a consecutive sampling technique from 30 patients suspected lung cancer who were treated at RSUD dr. Zainoel Abidin Banda Aceh in September 2024 to December 2024. Results: This research shows that Gun biopsy is a superior modality compared to TTNA with an AUC value of 0.833, accuracy of 76.3%, sensitivity of 66.7%, specificity of 100.0%, Positive Predictive Value (PPV) of 100.0% and Negative Predictive Value (NPV) of 56.3%. TTNA showed an AUC value of 0.762, accuracy 66.7, sensitivity 52.4%, specificity 100.0%, PPV 100.0% and NPV 47.4%. There was no difference in cell type results based on anatomical pathology examination between the two sampling techniques. Discussion: Sampling using gun biopsy can increase the detection rate of lung cancer. There were no significant differences in sample cell types in this study because the samples were taken from the same patient. Keywords: Lung Cancer, Teknik biopsi, Gun biopsy, Transthoracic Needle Aspiration