Electronic Theses and Dissertation

Pendahuluan : Aerva lanata (Linn.) mengandung sejumlah metabolit sekunder yang memiliki efek antifertilitas seperti alkaloid, tannin, saponin, steroid, dan flavonoid. Penelitian ini bertujuan melihat efek ekstrak ethanol Aerva lanata (Linn.) terhadap titik implantasi dan ketebalan endometrium mencit betina (Mus musculus).
Metode : Penelitian ini merupakan penelitian eksperimental laboratorik jenis The Postest Only Control Group Design dengan menggunakan rancangan acak lengkap (RAL) pola satu arah dengan lima perlakuan dan 5 ulangan. Ekstrak ethanol Aerva lanata (Linn.) diberikan sebanyak 0,2 cc per hari selama 10 hari dengan dosis 200 mg/KgBB, 400 mg/KgBB, 800 mg/KgBB, 1000 mg/KgBB. Sementara kelompok kontrol tidak diberikan perlakuan. Pada hari ke-12 kehamilan mencit diterminasi lalu diamati jumlah titik implantasi dan ketebalan endometrium. Data selanjutnya dianalisis dengan menggunakan Analisis Varian (ANOVA) pada taraf kepercayaan 95% dan uji lanjut Duncan Multiple New Range Test.
Hasil : Tidak ada satupun titik implantasi yang terbentuk pada kelompok 800 mg/KgBB dan 1000 mg/KgBB yang memiliki nilai yang signifikan dibandingkan dengan kelompok lainnya. Kelompok dosis 800 mg/KgBB dan 1000 mg/KgBB menyebabkan ketebalan endometrium yang semakin tipis. Semakin tinggi pemberian dosis ekstrak ethanol Aerva lanata (Linn) menyebabkan ketebalan endometrium semakin tipis sehingga tidak terbentuk titik implantasi pada mencit betina (Muss musculus Linn.).
Kesimpulan : Pemberian dosis besar ekstrak ethanol Aerva lanata (Linn) yaitu 800 mg/KgBB dan 1000 mg/KgBB menyebabkan semakin tipis ketebalan endometrium maka semakin sedikit jumlah titik implantasi yang terbentuk pada mencit betina (Muss musculus Linn.) sehingga dapat digunakan sebagai antifertilitas.
Kata Kunci : Aerva lanata (Linn.), antifertilitas, titik implantasi, ketebalan endometrium, Muss musculus

Introduction : Aerva lanata (Linn.) contains a number of secondary metabolites that have antifertility effects such as alkaloids, tannins, saponins, steroids, and flavonoids. This study aims to see the effects of ethanol extract of Aerva lanata (Linn.) on the implantation sites and endometrial thickness of female mice (Mus musculus). Methods : This study is an experimental laboratory study of the Posttest Only Control Group Design type using a completely randomized design (CRD) one-way pattern with five treatments and 5 replications. Ethanol extract of Aerva lanata (Linn.) was given as much as 0.2 cc per day for 10 days with doses of 200 mg/KgBW, 400 mg/KgBW, 800 mg/KgBW, 1000 mg/KgBW. While the control group was not given any treatment. On the 12th day of pregnancy, the mice were terminated and then the number of implantation sites and endometrial thickness were observed. The data were then analyzed using Analysis of Variance (ANOVA) at a 95% confidence level and followed by the Duncan Multiple New Range Test. Result : None of the implantation sites formed in the 800 mg/KgBB and 1000 mg/KgBB groups which had significant values compared to the other groups. The 800 mg/KgBB and 1000 mg/KgBB dose groups resulted in the endometrium to become thinner. The higher the dose of Aerva lanata (Linn) ethanol extract, the thinner the endometrial thickness seen, hence no implantation sites were formed in female mice (Muss musculus Linn.). Conclusion : Administration of higher doses of Aerva lanata (Linn) ethanol extract, namely 800 mg/KgBW and 1000 mg/KgBW, resulted in the thickness of the endometrium to become thinner, thus reducing the number of implantation sites formed in female mice (Muss musculus Linn.), hence it can be used as an antifertility agent. Keywords: Aerva lanata (Linn.), antifertility, implantation sites, endometrial thickness, Muss musculus