Electronic Theses and Dissertation

Rimpang kunyit (Curcuma longa) dikenal sebagai tanaman obat yang memiliki
berbagai manfaat kesehatan, salah satunya dalam pengembangan kontrasepsi berbasis herbal.
Kandungan senyawa aktifnya, seperti kurkumin, memiliki sifat antioksidan, antiinflamasi, dan
antifertilitas. Penelitian ini bertujuan untuk mengevaluasi pengaruh pemberian ekstrak rimpang
kunyit terhadap perkembangan spermatid tikus jantan. Penelitian dilakukan menggunakan
rancangan acak lengkap (RAL) dengan tiga kelompok perlakuan, yaitu kelompok kontrol tanpa
ekstrak kunyit (K), kelompok yang diberikan dosis 300 mg/kgBB (P1), dan kelompok yang
diberikan dosis 600 mg/kgBB (P2). Data variabel round spermatid, elongating spermatid,
elongated spermatid dianalisis menggunakan uji ANOVA dan uji lanjut Duncan. Hasil
penelitian menunjukkan bahwa pemberian ekstrak rimpang kunyit secara signifikan
memengaruhi jumlah elogated spermatid (P < 0,05) dengan jumlah masing-masing pada
Kelompok K, P1,dan P2 adalah 18,20±3,65; 5,16±4,85, 1,53±0,75 sel. Sedangkan variabel
round spermatid, elongating spermatid, dan total spermtid menunjukkan perbedaan yang tidak
signifikan (P > 0,05). Data yang didapatkan pada Kelompok K, P1,dan P2 untuk round
spermatid (53,36±22,11; 80,70±8,57; dan 83,16±25,16 sel), elongating spermatid
(38,46±18,50; 42,53±1,30, dan 42,60±10,33 sel), dan total spermatid (110±40,73, 128±2,68,
dan 127,29±25,59 sel). Kesimpulannya, ekstrak rimpang kunyit dengan berbagai dosis
memiliki pengaruh signifikan terhadap perkembangan elongated spermatid pada tikus Wistar.

Turmeric rhizome (Curcuma longa) is recognized as a medicinal plant with various health benefits, including its potential in the development of herbal-based contraception. Its active compounds, such as curcumin, possess antioxidant, anti-inflammatory, and antifertility properties. This study aims to evaluate the effects of turmeric rhizome extract on the development of spermatids in male rats. The research was conducted using a completely randomized design (CRD) with three treatment groups: a control group without turmeric extract (K), a group receiving a dose of 300 mg/kg body weight (P1), and a group receiving a dose of 600 mg/kg body weight (P2). Data on round spermatid, elongating spermatid, and elongated spermatid variables were analyzed using ANOVA and Duncan's post hoc test. The results indicated that the administration of turmeric rhizome extract significantly affected the number of elongated spermatids (P < 0.05), with the respective counts in groups K, P1, and P2 being 18.20 ± 3.65; 5.16 ± 4.85; and 1.53 ± 0.75 cells. Meanwhile, the round spermatid, elongating spermatid, and total spermatid variables showed no significant differences (P > 0.05). The data obtained for round spermatids in groups K, P1, and P2 were 53.36 ± 22.11; 80.70 ± 8.57; and 83.16 ± 25.16 cells, respectively, while the elongating spermatids were 38.46 ± 18.50; 42.53 ± 1.30; and 42.60 ± 10.33 cells, and the total spermatids were 110 ± 40.73; 128 ± 2.68; and 127.29 ± 25.59 cells. In conclusion, turmeric rhizome extract at various doses significantly influences the development of elongated spermatids in Wistar rats.