Electronic Theses and Dissertation

Latar Belakang: Kelainan tiroid merupakan kondisi dimana seseorang mengalami perubahan fungsi maupun bentuk dari kelenjar tiroid. Perubahan ini dapat berupa hipotiroidisme atau hipertiroidisme. Dasar dalam mendiagnosisnya yaitu pemeriksaan kadar Thyroid Stimulating Hormone Sensitive (TSHS) dan diikuti pengukuran tiroksin bebas (FT4) dan triiodotironin bebas (FT3). Pemeriksaan autoantibodi berupa Thyrotropin receptor antibody (TRAb) dan Anti thyroid peroxidase antibody (TPOAb) untuk mendeteksi adanya penyakit autoimun yang menyerang kelenjar tiroid. Pemeriksaan laboratorium yang akurat dan tepat waktu sangat penting untuk diagnosis yang benar dan perawatan yang efektif bagi penderita penyakit tiroid. Tujuan : Penelitian ini bertujuan untuk mengetahui pengaruh kadar TRAb dan kadar TPOAb terhadap umur, jenis kelamin, kadar FT4 dan kadar TSHS. Metode: Desain penelitian ini mengunakan analitik observasional dengan rancangan cross sectional sejak 3 januari 2025. Penelitian dilakukan di laboratorium swasta dengan mencatat rekam medis berupa umur, jenis kelamin, kadar TSHS, kadar FT4, kadar TRAb dan kadar TSHS. Data dianalisis secara bivariat dengan uji korelasi pearson dan uji T, uji mann whitney dan uji korelasi spearman. Hasil : Diperoleh 133 sampel TRAb dan 27 sampel TPOAb. Mayoritas perempuan (92,6% pada TRAb dan 85% pada TRAb) dengan rentang usia 26-45 tahun. Kadar TRAb berhubungan dengan jenis kelamin (p=0,01) namun kadar TPOAb tidak berhubungan dengan jenis kelamin (p=0,752). Kadar TRAb dan kadar TPOAb berhubungan dengan kadar TSHS (p=0,01 dan p=0,03), namun tidak berhubungan dengan umur dan kadar FT4. Kesimpulan : Terdapat hubungan kadar TRAb terhadap jenis kelamin dan TSHS dan kadar TPOAb terhadap jenis kelamin. Kata Kunci : Kelainan Fungsi Hormon Tiroid, TRAb, TPOAb, Autoantibodi

Background: Thyroid disorders are conditions in which a person experiences changes in the function or shape of the thyroid gland, which can manifest as hypothyroidism or hyperthyroidism.The diagnosis of thyroid disorders is based on the examination of Thyroid Stimulating Hormone Sensitive (TSHS) levels, followed by measurement of free thyroxine (FT4) and free triiodothyronine (FT3). Furthermore, the presence of autoantibodies, such as thyrotropin receptor antibody (TRAb) and anti-thyroid peroxidase antibody (TPOAb), can be detected through laboratory testing. These autoantibodies indicate the presence of autoimmune diseases that target the thyroid gland. Accurate and timely laboratory tests are paramount for the diagnosis and effective treatment of patients with thyroid disease. Objective: The objective of this study is to ascertain the impact of TRAb and TPOAb levels on age, gender, FT4 and TSHS levels. Methods: The research design utilised observational analytics with a cross-sectional design, commencing on 3 January 2025. The study was conducted in a private laboratory, wherein medical records were meticulously recorded. These records encompassed age, gender, thyroid-stimulating hormone (TSH) levels, free triiodothyronine (FT4) levels, and thyrotropin receptor antibody (TRAb) levels. Subsequent to the collection of the data, it underwent rigorous analysis employing a variety of analytical methods, including Pearson's correlation test, T-test, Mann-Whitney test, and Spearman's correlation test. Results: A total of 133 TRAb and 27 TPOAb samples were obtained for the study. The majority of the subjects were female (92.6% for TRAb and 85% for TPOAb), with an age range of 26-45 years. TRAb levels were found to be associated with gender (p=0.01), while TPOAb levels did not demonstrate a similar association (p=0.752). Furthermore, both TRAb and TPOAb levels demonstrated a correlation with TSHS levels (p=0.01 and p=0.03, respectively), though this association was not observed between age and FT4 levels. Conclusion: There is an association of TRAb levels with gender and TSHS and TPOAb levels with gender. Keywords: Thyroid Hormone Function Abnormalities, TRAb, TPOAb, Autoantibodies