Electronic Theses and Dissertation

Endometriosis merupakan peradangan kronis yang ditandai pertumbuhan jaringan yang menyerupai endometrium di luar rahim, menyebabkan nyeri panggul, infertilitas, dan jaringan parut. Ekstrak daun C. odorata kaya akan senyawa bioaktif seperti flavonoid, tanin, saponin, dan alkaloid, yang memiliki sifat antiinflamasi, antioksidan, antimikroba, serta antikanker. Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak daun C. odorata terhadap penurunan luas implan endometrium dan gambaran histopatologis endometrium pada mencit model endometriosis. Penelitian ini merupakan penelitian ekperimental dengan rancangan post test only control group design. Jaringan endometrium berasal dari mencit endometriosis sebanyak 12 ekor yang dibagi menjadi 4 kelompok, K0 merupakan kelompok mencit endometriosis, K1, K2, dan K3 merupakan kelompok mencit endometriosis yang mendapatkan perlakuan ekstrak daun C. odorata dengan dosis 200, 400 dan 800 mg/kg bb. Jaringan diproses menjadi preparat histologi dan diwarnai dengan pewarnaan HE. Variabel yang diamati yaitu luas implan endometrium dan gambaran histopatologis jaringan berupa proliferasi sel stroma, infiltrasi makrofag, dan angiogenesis. Data kuantitatif dianalisis dengan uji ANOVA, sedangkan data kualitatif dianalisis secara deskriptif. Hasil penelitian diketahui bahwa luas implan endometrium pada kelompok mencit yang diberi ekstrak daun C. odorata (K1, K2, K3) lebih kecil secara signifikan dibandingkan kelompok K0 (p

Endometriosis is a chronic inflammation characterized by the growth of endometrial-like tissue outside the uterus, causing pelvic pain, infertility, and scarring. C. odorata leaf extract is rich in bioactive compounds such as flavonoids, tannins, saponins, and alkaloids, which have anti-inflammatory, antioxidant, antimicrobial, and anticancer properties. The purpose of this study was to determine the effect of C. odorata leaf extract on reducing the area of endometrial implants and histopathological features of the endometrium in an endometriosis mice model. This research is an experimental research with a post-test only control group design. The peritoneal tissue came from 12 endometriosis mice divided into 4 groups, K0 is a group of endometriosis mice, K1, K2, and K3 are groups of endometriosis mice treated with C. odorata leaf extract at doses of 200, 400 and 800 mg/kg weight. Tissue were processed into histological preparations and stained with HE staining. The variables observed were the area of the endometrium implant and histopathology of the tissue in the form of stromal cell proliferation, macrophage infiltration, and angiogenesis. Quantitative data were analyzed using the ANOVA test, while qualitative data were analyzed descriptively. The results of the study showed that the area of endometrium implants in the group of mice given C. odorata leaf extract (K1, K2, K3) was significantly smaller than the K0 group (p