Electronic Theses and Dissertation

Luka sayat termasuk luka terbuka yang terjadi akibat rusaknya lapisan dalam suatu jaringan kulit. Penelitian ini bertujuan untuk menganalisis gambaran patologi anatomi penyembuhan luka sayat yang diobati dengan gel dan krim ekstrak daun kersen (Muntingia calabura L) pada konsentrasi 5%, 10%, dan 15% pada tikus putih (Rattus norvegicus), serta untuk menentukan formulasi dan konsentrasi yang paling efektif dalam mempercepat penyembuhan luka. Parameter yang diamati mencakup panjang luka, kemerahan, edema, awal terbentuk keropeng, dan lepas keropeng. Sebanyak 21 ekor tikus putih jantan, bobot badan 150-200 gram berumur 7-8 minggu. Luka sayat dilakukan di daerah punggung sepanjang 2 cm. Perawatan luka dilakukan dua kali sehari selama 14 hari yaitu kontrol negatif P0 diberikan NaCl 0,9%, kelompok perlakuan gel P1, P2, dan P3 masing-masing diberikan gel ekstrak daun kersen 5%, 10%, dan 15% dan kelompok P4, P5, dan P6 masing-masing diberikan krim ekstrak daun kersen 5%, 10%, dan 15%. Hasil penelitian menunjukkan bahwa pemberian krim ekstrak daun kersen dengan konsentrasi 10% dapat mempercepat penyembuhan luka sayat. Berdasarkan gambaran patologi anatomi, pemberian ekstrak daun kersen dalam bentuk sediaan gel dan krim dapat mempercepat penyembuhan luka sayat, dengan sediaan krim ekstrak daun kersen menunjukkan efektivitas terbaik. Krim ekstrak daun kersen konsentrasi 10% secara patologi anatomi terbukti paling baik diantara kelompok sediaan krim. Sedangkan, pada kelompok sediaan gel, gel ekstrak daun kersen 5% yang paling efektif. Secara keseluruhan, krim ekstrak daun kersen 10% memberikan hasil terbaik dalam penyembuhan luka sayat.

Incision wound were classified as open wounds that occurred due to damage to the inner layers of skin tissue. This study aimed to investigate the anatomical pathology of the healing of incision wound treated with gels and creams of cherry leaf extract (Muntingia calabura L) at concentrations of 5%, 10%, and 15% in white rats (Rattus norvegicus). The observed parameters included wound length, redness, edema, the initial formation of scabs, and scab detachment. A total of 21 male white rats, weighing between 150-200 grams and aged 7-8 weeks, were used. A 2 cm long incision was made on the dorsal area of the rats. Wound care was performed twice daily for 14 days, with the negative control group (P0) receiving NaCl 0,9%, while the treatment groups P1, P2, and P3 were given gels of cherry leaf extract at 5%, 10%, and 15%, respectively. Groups P4, P5, and P6 received creams of cherry leaf extract at 5%, 10%, and 15%, respectively. The results showed that the application of 10% leaf extract cream significantly accelerated wound healing. Based on the anatomical pathology observations, it can be concluded that the administration of kersen leaf extract in the form of gel and cream could accelerate the healing of incision wounds with the cream formulation showing the best effectiveness. The 10% kersen leaf extract cream was proven to be the most effective in terms of pathological anatomy among the cream groups. Meanwhile, in the gel formulation group, the 5% kersen leaf extract gel was the most effective. Overall, the 10% kersen leaf extract cream provided the best results in healing incised wounds.