Electronic Theses and Dissertation

ABSTRACT
Citicoline (CDP-choline) is an endogenous compound that serves as an
intermediate compound in the synthesis of membrane phospholipids, acetylcholine
synthesis and as a metal donor. Citicoline can provide cholinergic and
neuroprotective effects. Citicoline can also improve the structural and functional
integrity of nerve cell membranes and helps repair cell membranes during cell
injury. The purpose of this study was to determine the role of citicoline on functional
status pascacedera sciaticus nerve. This study is an experimental laboratory study
using 40 male white rats (Rattus norvegicus.). Rats were divided into 4 experimental
groups: the group I as a positive control group, group II as a negative control group,
while group III, IV as a treatment group. Positive control group is a group that is
covered with gelatin sponge soaked with 0.4 cc of saline solution 0.9%, the negative
control group was not given the treatment while the treatment group is the group
that was wrapped with a gelatin sponge soaked with citicoline 0.4 cc and 0.8 cc
citicoline. Assessment of functional status can be done by the method of walking
track. This method is done by letting the animals walk on the white paper along the
100 m with a given compartment is dark. From the analysis of walking tracks and
followed by a graphic analysis found that citicoline role in the improvement of
functional status. It can be concluded that citicoline may play a role in the process of
improving functional status pascacedera sciaticus nerve in the rat.
Keyword : Functional status, citicoline

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