Electronic Theses and Dissertation

Salmonella sp. seringkali bersifat patogen terhadap manusia karena mampu bertahan
hidup di dalam makrofag. Penyakit salmonellosis perlu menjadi perhatian karena
banyaknya resistensi bakteri terhadap antibiotik yang terjadi. Penelitian ini bertujuan
untuk mengetahui proporsi kasus dan distribusi kasus infeksi Salmonella sp.
berdasarkan jenis kelamin, kelompok umur, jenis spesies, dan ruang rawat pasien, serta
mengevaluasi kepekaan antibiotik Salmonella sp. Metode penelitian yang digunakan
adalah observasional deskriptif dengan mengumpulkan data (retrospektif dan
prospektif) hasil kultur Salmonella sp. dari seluruh spesimen klinis mulai periode 1
Januari 2015 – 6 Juni 2024. Sampel klinis yang diterima dilakukan isolasi, identifikasi,
dan uji kepekaan Salmonella sp. yang diisolasi terhadap antibiotik. Hasil penelitian ini
menunjukkan jumlah kasus akibat infeksi Typhoidal Salmonella pada 10 tahun
terakhir ialah sebanyak 28 kasus (35,90%), sedangkan akibat infeksi Non-Typhoidal
Salmonella sebanyak 50 kasus (64,10%). Distribusi kasus tertinggi berdasarkan jenis
kelamin oleh kelompok Typhoidal Salmonella ditemukan pada perempuan sebanyak
21 kasus (26,92%), sedangkan oleh Non-Typhoidal Salmonella juga pada perempuan
sebanyak 26 kasus (33,34%). Distribusi kasus tertinggi berdasarkan usia pada
kelompok Typhoidal Salmonella adalah rentang usia 26-45 tahun sebanyak 13 kasus
(16,67%), sedangkan kelompok Non-Typhoidal Salmonella di atas 45 tahun sebanyak
34 kasus (43,59%). Distribusi kasus tertinggi berdasarkan jenis spesimen pada
kelompok Typhoidal Salmonella adalah spesimen darah sebanyak 19 kasus (24,36%),
sedangkan Non-Typhoidal Salmonella adalah spesimen pus sebanyak 22 kasus
(28,21%). Distribusi kasus tertinggi berdasarkan ruang rawat inap pada kelompok
Typhoidal Salmonella adalah ruang rawat intensive sebanyak 16 pasien (20,51%),
sedangkan Non-Typhoidal Salmonella adalah ruang rawat penyakit dalam sebanyak
18 pasien (23,1%). Spesies yang masih sangat sensitif terhadap banyak antibiotik
adalah Salmonella typhi, Salmonella Paratyphi A, dan Salmonella spp.

Salmonella sp. are often pathogenic to humans because they can survive in macrophages. Salmonellosis disease needs to be a concern because of many bacterial resistances to antibiotics that occur. This study aims to determine the proportion of cases and distribution of Salmonella sp. cases based on gender, age group, species type, and patient hospitalization room, as well as evaluate the antibiotic sensitivity of Salmonella sp. The research method used was descriptive observational by collecting data (retrospectively and prospectively) of Salmonella sp. culture results from all clinical specimens from the period January 1, 2015 - June 6, 2024. The clinical samples received were isolated, identified, and tested the sensitivity of Salmonella sp. isolated to antibiotics. The results of this study showed the number of cases due to Typhoidal Salmonella in the last 10 years was 28 cases (35.90%), while due to the Non-Typhoidal Salmonella group was 50 cases (64.10%). The highest distribution of cases based on gender in the Typhoidal Salmonella group was found in females as many as 21 cases (26.92%), while Non-Typhoidal Salmonella was also in females as many as 26 cases (33.34%). The highest distribution of cases by age in the Typhoidal Salmonella group was in the age range of 26-45 years as many as 13 cases (16.67%), while the Non Typhoidal Salmonella group was above 45 years as many as 34 cases (43.59%). The highest distribution of cases based on the type of specimen in the Typhoidal Salmonella group was blood specimens as many as 19 cases (24.36%), while Non Typhoidal Salmonella was pus specimens as many as 22 cases (28.21%). The highest distribution of cases based on the hospitalization room in the Typhoidal Salmonella group was the intensive care unit as many as 16 patients (20.51%), while Non Typhoidal Salmonella was the internal medicine unit as many as 18 patients (23.1%). Species that are still very sensitive to many antibiotics are Salmonella typhi, Salmonella Paratyphi A, and Salmonella spp.