Electronic Theses and Dissertation

ABSTRAK

Pendahuluan: Vitamin D termasuk vitamin yang sangat berperan dalam proses biosintesis hormon pada wanita. Terganggunya regulasi hormonal tubuh dapat menimbulkan berbagai kondisi patologi pada wanita seperti kejadian Sindroma ovarium polikistik (SOPK) yang sering terjadi pada wanita usia produktif. Kejadian SOPK berkaitan dengan resistensi insulin dan resiko komplikasi metabolik lain. Penelitian ini bertujuan untuk menilai pengaruh pemberian vitamin D terhadap perubahan kadar HbA1C pada penderita SOPK.
Metode: penelitian ini menggunakan desain Randomized control trial (parallel trial). Kelompok intervensi diberikan suplementasi vitamin D 50.000 IU setiap minggu selama 8 minggu. Pemeriksaan kadar HbA1C dilakukan sebelum dan setelah intervensi. Analisis Mann-Whitey U test digunakan dalam penelitian ni dengan tingakat kepercayaan 95%.
Hasil: Sebanyak 36 subjek penderita SOPK terlibat dalam penelitian ini yang tebagi sebanyak 19 orang pada masing – masing kelompok. Rerata kadar HbA1C pada kelompok SOPK sebelum dan setelah mendapat vitamin D tidak mengalami perubahan signifikan yakni sebesar 5,3%. Tidak terdapat perbedaaan perubahan kadar HbA1C antar kelompok dengan dan tanpa pemberian vitamin D (p = 1,000).
Kesimpulan: Pemberian suplementasi vitamin D tidak mempengaruhi perubahan kadar HbA1C pada penderita SOPK. Vitamin D berperan penting dalam regulasi hormon reproduksi dan potensial digunakan dalam manajemen SOPK dengan dosis dan waktu suplementasi yang tepat.

Kata Kunci: SOPK, vitamin D, HbA1C

ABSTRACT Introduction: Vitamin D is a vitamin that plays an important role in the process of hormone biosynthesis in women. Disruption of the body's hormonal regulation can cause various pathological conditions in women, such as polycystic ovary syndrome (PCOS), which is most common in women of reproductive age. The incidence of PCOS is related to insulin resistance and the risk of other metabolic complications. This study aims to assess the effect of vitamin D administration on changes in HbA1C levels in PCOS sufferers. Method: This study used a randomized control trial (parallel trial) design. The intervention group was given 50,000 IU vitamin D supplementation every week for 8 weeks. HbA1C levels were checked before and after the intervention. Mann-Whitey U test analysis was used in this study with a confidence level of 95%. Results: A total of 36 subjects suffering from PCOS were involved in this research, divided into 19 people in each group. The mean HbA1C level in the PCOS group before and after receiving vitamin D did not experience a significant change, namely 5.3%. There was no difference in changes in HbA1C levels between groups with and without vitamin D administration (p = 1,000). Conclusion: Vitamin D supplementation does not affect changes in HbA1C levels in PCOS sufferers. Vitamin D plays an important role in the regulation of reproductive hormones and has the potential to be used in the management of PCOS with the right dose and timing of supplementation. Keywords: HbA1C, PCOS, vitamin D