Electronic Theses and Dissertation

KORELASI RASIO NETROFIL LIMFOSIT, RASIO TROMBOSIT LIMFOSIT DAN KADAR INTERLEUKIN 6 TERHADAP DERAJAT DEPRESI PADA PASIEN PENYAKIT GINJAL KRONIK YANG MENJALANI HEMODIALISIS

Latar Belakang: Terdapat 20 – 40% populasi yang menjalani hemodialisis terbukti menderita depresi. Depresi telah dihubungkan dengan respon inflamasi sistemik. Rasio Netrofil Limfosit, Rasio Trombosit Limfosit dan Interlukin-6 saat ini telah dikemukakan sebagai indikator yang baik dalam menggambarkan status inflamasi. Kejadian depresi pada penderita Penyakit Ginjal Kronik (PGK) dapat memperberat kondisi dan luaran penyakit. Penelitian ini bertujuan untuk menilai korelasi penanda inflamasi terhadap derajat depresi pada penderita PGK yang menjalani hemodialisis secara regular.
Metode: Penelitian ini termasuk studi observasional dengan desain potong lintang yang dilakukan pada Rumah Sakit Umum Daerah dr. Zainoel Abdin Banda Aceh. Penilaian penanda inflamasi pada penelitian ini dilakukan menggunakan tiga parameter mencakup Rasio Netrofil Limfosit (RNL), Rasio Trombosit Limfosit (RTL), dan Interleukin (IL)-6. Beck Depression Inventory (BDI) dilakukan untuk menilai tingkatan depresi pada penderita PGK. Analisis Spearman Rank test digunakan dalam penelitian ini dengan tingkat kepercayaan 95%.
Hasil: Sebanyak 64 subjek terlibat dalam penelitian ini dengan distribusi 25 orang depresi ringan, 13 orang depresi sedang, 9 orang depresi berat dan 17 orang tanpa depresi dengan Skor BDI pada penderita PGK memiliki rerata 13 dan penanda inflamasi mencakup RNL sebesar 3% (p

CORRELATION OF NEUTROPHILE-LYMPHOCYTE RATIO, PLATELET-LYMPHOCYTE RATIO AND INTERLEUKIN 6 LEVELS TO THE DEGREE OF DEPRESSION IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALISIS Background: There are 20 – 40% of the population undergoing hemodialysis who are proven to suffer from depression. Depression has been linked to a systemic inflammatory response. Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Interlukin-6 have now been put forward as good indicators in describing inflammatory status. The incidence of depression in sufferers of Chronic Kidney Disease (CKD) can worsen the condition and outcome of the disease. This study aims to assess the correlation of inflammatory markers with the degree of depression in CKD sufferers who undergo regular hemodialysis. Method: This research included an observational study with a cross-sectional design conducted at the Regional General Hospital dr. Zainoel Abdin Banda Aceh. Assessment of inflammatory markers in this study was carried out using three parameters including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and interleukin (IL)-6. Beck Depression Inventory (BDI) was carried out to assess the level of depression in CKD. Spearman Rank test analysis was used in this study with a confidence level of 95%. Result: There were 64 patients were involved in this study with a distribution of 25 patients with mild depression, 13 patients with moderate depression, 9 patients with severe depression and 17 patients without depression. The BDI score in CKD sufferers had a mean of 13 and inflammatory markers included NLR of 3% (p