Electronic Theses and Dissertation

Tuberkulosis Resistan Obat (TB RO) merupakan penyakit tuberkulosis yang telah kebal terhadap Obat Anti Tuberkulosis (OAT) akibat mutasi strain bakteri Mycobacterium tuberculosis. Paduan pengobatan TB RO menggunakan obat yang banyak, sehingga berisiko menimbulkan efek samping salah satunya terjadi pemanjangan interval QT yang dapat mengakibatkan Torsades de Pointes oleh paduan obat yang mengandung bedaquline, levofloxacin/ moxifloxacin, clofazimin dan delamanid. Penelitian ini bertujuan meneliti efek samping pengunaan OAT pada jantung berupa pemanjangan interval QT pada pasien TB RO. Jenis penelitian observasional deskriptif dengan teknik total sampling. Penelitian dilaksanakan di Poli TB RO Instalasi Pelayanan Tuberkulosis Terpadu RSUD dr. Zainoel Abidin Banda Aceh dengan sampel pasien TB RO periode Januari 2021–Desember 2022 sebanyak 37 orang sesuai dengan kriteria.Hasil penelitian menunjukan bahwa proporsi pasien TB RO yang mengalami pemanjangan interval QTc sebanyak 17 orang (45,9%) dan yang tidak mengalami pemanjangan interval QTc 20 orang (54,1%). Pemanjangan interval QTc paling banyak terjadi dalam pengobatan regimen jangka Panjang, yaitu sebanyak 5 orang (46,9%), insidensi pemanjangan interval QTc terbanyak pada bulan pertama dan bulan ketiga sebanyak (18,9%), pada kelompok usia 17-25 tahun sebanyak 6 orang (85,7%), jenis kelamin laki-laki sebanyak 12 orang (48%), kelompok IMT < 18,5 sebanyak 9 orang (47,4%), pada pasien dengan hipoalbumin 9 orang (52,9%), serta kelompok elektrolit dengan hipokalemia 1 orang (20%), komorbiditas terbanyak yaitu Diabetes Mellitus dengan jumlah 5 orang (31,25%). Kesimpulan, pasien TB RO paling banyak mengalami pemanjangan interval QTc dengan jenis kelamin laki-laki, usia 17-25 tahun, serta IMT < 18,5.

Drug-resistant tuberculosis (DR-TB) is a tuberculosis disease that has become resistant to anti-tuberculosis drugs (OAT) due to mutations of the Mycobacterium tuberculosis bacterial strain. The combination of DR-TB treatment uses a lot of drugs, so there is a risk of side effects, one of which is the prolongation of the QT interval which can cause Torsades de Pointes by a drug combination containing bedaquline, levofloxacin / moxifloxacin, clofazimin and delamanid. This study aims to examine the side effects of OAT use on the cardiac in the form of QT interval in patients with DR- TB. Descriptive observational research with total sampling technique. The research was conducted at TB RO Poli, Integrated Tuberculosis Service Installation at RSUD dr. Zainoel Abidin Banda Aceh with sample 37 DR-TB patients from January 2021- December 2022 according to the criteria. The results showed that the proportion of DR-TB patients who experienced QT interval prolongation were 17 people (45.9%) and those who did not experience QT interval prolongation were 20 people (54.1%). QT interval prolongation occurred mostly in long-term treatment regimens, namely 5 people (46.9%),the highest incidence of QT interval prolongation in first and third month as many as (18.9%), in the age group 17-25 years were 6 people (85.7%),male gender were 12 people (48%), IMT < 18.5 group were 9 people (47.4%),patients with hypoalbumin 9 people (52.9%),electrolyte group with hypokalemia 1 person (20%), the most comorbidities are Diabetes Mellitus with a total of 5 people (31.25%). In conclusion, DR-TB patients mostly experienced QT interval prolongation with male gender, age 17-25 years, and BMI < 18.5.