Electronic Theses and Dissertation

ABSTRAK
Pendahuluan : Proporsi infeksi laten tuberkulosis pada pasien penyakit ginjal
kronik cukup tinggi, tetapi belum banyak data dan referensi yang mendukung
khususnya di Provinsi Aceh dan Rumah Sakit Umum Daerah dr. Zainoel Abidin.
Tujuan penelitian adalah mengetahui proporsi dan faktor risiko yang
mempengaruhi terjadinya infeksi laten tuberkulosis pada pasien penyakit ginjal
kronik dengan hemodialisis rutin.
Metode : Penelitian ini merupakan penelitian analitik observasional dengan
rancangan cross-sectional yang bertempat di ruang Instalasi Hemodialisis Rumah
Sakit Umum Daerah dr. Zainoel Abidin, pengambilan sampel dilakukan pada
bulan Juni-Agustus tahun 2023 dengan cara non-probability sampling
menggunakan teknik consecutive sampling.
Hasil : Populasi pasien penyakit ginjal kronik yang menjalani hemodialisis rutin
berjumlah 289 subjek, 235 subjek dikeluarkan dan 54 subjek memenuhi kriteria
inklusi. Proporsi infeksi laten tuberkulosis pada pasien penyakit ginjal kronik
adalah 27,8%. Analisis statistik menggunakan uji Chi Square dan Mann Whitney
dengan Confidence Interval 95% dan α 0,05 menunjukkan tidak terdapat hubungan
faktor risiko umur, jenis kelamin, indeks massa tubuh, status merokok, etiologi
penyakit ginjal kronik dengan kejadian infeksi laten tuberkulosis (p value > 0,05).
Analisis statistik multivariat tidak dapat dilakukan karena p value > 0,25.
Kesimpulan : Penelitian menunjukkan tidak terdapat hubungan antara faktor
risiko dengan kejadian infeksi laten tuberkulosis, karena pasien penyakit ginjal
kronik mengalami gangguan imunodefisiensi yang berat. Rendahnya partisipan
dalam penelitian ini disebabkan oleh rendahnya tingkat kesadaran, pengetahuan
dan pendidikan serta anggapan tindakkan Tuberculin Skin Test sangat berisiko
untuk pasien penyakit ginjal kronik.

Kata Kunci : Tuberkulosis, Infeksi Laten Tuberkulosis, Penyakit Ginjal Kronik,
Tuberculin Skin Test, Hemodialisis.

ABSTRACT Introduction : The proportion of latent tuberculosis in chronic kidney disease patients is high, but there are not many supporting data and references, especially in Aceh and Doctor Zainoel Abidin Regional General Hospital. The aim of the study was to determine the proportion and risk factors affecting the occurrence of latent tuberculosis in chronic kidney disease patients with routine haemodialysis. Methods : This study was an observational analytic study with a cross-sectional design that took place in the Hemodialysis Installation room at Doctor Zainoel Abidin Regional General Hospital, sampling was conducted in June-August 2023 by non-probability sampling using consecutive sampling technique. Results : The population of chronic kidney disease patients undergoing routine haemodialysis was 289 subjects, 235 subjects were excluded and 54 subjects met the inclusion criteria. The proportion of latent tuberculosis infection in chronic kidney disease patients was 27.8%. Statistical analysis using Chi Square and Mann Whitney tests with 95% Confidence Interval and α 0.05 showed no association of risk factors of age, gender, body mass index, smoking status, etiology of chronic kidney disease with the incidence of latent tuberculosis infection (p value > 0.05). Multivariate statistical analysis could not be performed because the p value > 0.25. Discussion : The study showed no association between risk factors and the incidence of latent tuberculosis infection, because patients with chronic kidney disease have severe immunodeficiency disorders. The low number of participants in this study was due to the low level of awareness, knowledge and education as well as the assumption that Tuberculin Skin Test is very risky for patients with chronic kidney disease. Keywords : Tuberculosis, Latent Tuberculosis, Chronic Kidney Disease, Tuberculin Test, Hemodialysis.