Electronic Theses and Dissertation

Pendahuluan: Ventilator-associated pneumonia (VAP) adalah infeksi terkait perawatan kesehatan yang paling umum di antara pasien di intensive care unit (ICU) dan memiliki tingkat kematian tertinggi. Sirkuit ventilator merupakan reservoir penyebaran patogen nosokomial pada pasien ICU. Sirkuit ventilator terkontaminasi dengan cepat setelah ventilasi, dan tingkat kontaminasi tampaknya meningkat dari waktu ke waktu, dimana adaptor Y merupakan area paling terkontaminasi dalam 24 jam pertama. Metodologi Penelitian: Penelitian ini merupakan studi deskriptif analisis dengan pendekatan prospektif. Sebanyak 45 pasien yang memenuhi kriteria inklusi dan ekslusi menjadi sampel penelitian ini. Selanjutnya, dilakukan penilaian kultur bakteri dan identifikasi bakteri. Hasil Penelitian: Berdasarkan analisis data didapatkan profil bakteri terbanyak pada sirkuit pernapasan ventilator baik sebelum maupun sesudah digunakan adalah Klebsiella pneumoniae berturut-turut sebanyak 17.8% dan 22.2%. Dari 12 ventilator didapatkan paling banyak isolat tidak ada pertumbuhan bakteri baik sebelum maupun setelah 48 jam digunakan, diikuti oleh Klebsiella pneumoniae dan Acinetobacter baumannii. Analisis menggunakan chi-square didapatkan tidak ada hubungan antara riwayat penggunaan antibiotik dengan pertumbuhan pada kultur. Kesimpulan: Klebsiella pneumoniae merupakan isolat terbanyak yang tumbuh pada sirkuit ventilator di ICU RSUDZA. Oleh karena itu penting untuk melakukan pemeriksaan mikrobiologi dan uji kerentanan antibiotik pada setiap pasien VAP

Backgorund: Ventilator-associated pneumonia (VAP) is the most common healthcare-associated infection among patients in intensive care units (ICUs) and has the highest mortality rate. The ventilator circuit is a reservoir for the spread of nosocomial pathogens in ICU patients. The ventilator circuit becomes contaminated quickly after ventilation, and the level of contamination appears to increase over time, with the Y adapter being the most contaminated area in the first 24 hours. Research Methodology: This research is a descriptive analysis study with a prospective approach. A total of 45 patients who met the inclusion and exclusion criteria were included as the sample for this study. Next, bacterial culture assessment and bacterial identification were carried out. Results: Based on data analysis, it was found that the most common bacterial profile in the ventilator breathing circuit both before and after use was Klebsiella pneumoniae at 17.8% and 22.2% respectively. Among the 12 ventilators, the majority showed no bacterial growth either before or after 48 hours of use, followed by Klebsiella pneumoniae and Acinetobacter baumannii. Analysis using chi-square showed that there was no relationship between the history of antibiotic use and growth on culture. Conclusion : Klebsiella pneumoniae is the most common isolate that grows on the ventilator circuit in the RSUDZA ICU. Therefore, it is important to carry out microbiological examination and antibiotic susceptibility testing on every VAP patient