Electronic Theses and Dissertation

Latar Belakang: Anemia pada talasemia-β mayor memerlukan transfusi darah rutin yang dapat berakibat terjadi penumpukan besi sehingga jaringan dan organ seperti jantung, hati dan kelenjar endokrin mengalami kerusakan. Komplikasi kelebihan zat besi salah satunya yaitu gangguan pertumbuhan dan perkembangan seperti perawakan pendek. Penumpukan zat besi di kelenjar tiroid dapat dinilai dengan pemeriksaan TSH dan FT4.
Tujuan: Untuk mengetahui hubungan antara kadar TSH dan FT4 terhadap tinggi badan pada anak usia 8-18 tahun dengan talasemia-β mayor di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh?
Metode: Penelitian ini studi observasional dengan desain penelitian cross sectional. Sampel anak usia 8-18 tahun dengan talasemia-β mayor yang berobat di Poli Sentra Talasemia RSUDZA Banda Aceh. Analisa penelitian dengan uji korelasi Spearman.
Hasil: Sebanyak 51 anak talasemia-β mayor berusia 8-18 tahun memiliki kadar FT4 8.64-23.3 pmol/L dan kadar TSH antara 0.65-11.72 µIU/mL. Sekitar 98 % (50 anak) kadar TSH dan FT4 normal dan 1 anak (2 %) dengan kadar TSH yang tinggi, kadar FT4 normal. Arah dan koefisien korelasi kadar TSH dengan tinggi badan adalah – 0.319 (nilai p 0.022).
Kesimpulan: Terdapat hubungan yang lemah antara kadar TSH dengan tinggi badan anak talasemia-β mayor yang berusia 8-18 tahun dan tidak terdapat hubungan bermakna antara kadar FT4 terhadap tinggi badan anak talasemia-β mayor yang berusia 8-18 tahun di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh

Kata kunci: talasemia-β mayor, TSH, FT4, dan tinggi badan.

Background: Anemia in β-thalassemia major requires routine blood transfusions which can result in an accumulation of iron so that tissues and organs such as the heart, liver and endocrine glands are damaged. Complications of iron overload is growth and development disorders such as short stature. The accumulation of iron in the thyroid gland can be assessed by examination of TSH and FT4. Objective: To determine the relationship between TSH and FT4 levels on the height of children aged 8-18 years with β-thalassemia major at the Regional General Hospital dr. Zainoel Abidin Banda Aceh? Methods: This research is an observational study with a cross-sectional research design. Samples of children aged 8-18 years with β-thalassemia major who are treated at the Thalassemia Poly Center at the RSUDZA Banda Aceh. Research analysis with Spearman correlation test. Results: A total of 51 β-thalassemia major children aged 8-18 years, FT4 levels of 8.64-23.3 pmol/L and TSH levels between 0.65-11.72 µIU/mL. Approximately 98% (50 children) of normal TSH and FT4 levels and 1 child (2%) with high TSH levels, normal FT4 levels. The direction and correlation coefficient of TSH levels with height is – 0.319 (p value 0.022). Conclusion: There is a weak relationship between TSH levels and the height of β-thalassemia major children aged 8-18 years and there is no significant relationship between FT4 levels and the height of β-thalassemia major children aged 8-18 years at the Regional General Hospital dr. Zainoel Abidin Banda Aceh Keywords: thalassemia-β major, TSH, FT4, and height.