Electronic Theses and Dissertation

Infeksi merupakan penyakit yang sering diderita oleh pasien yang sedang dirawat di ruang Intensive Care Unit (ICU). Salah satu pengobatan infeksi adalah antibiotik. Penggunaan antibiotik yang tidak tepat merupakan faktor penyumbang resistensi antibiotik. Metode Gyssens digunakan dengan tujuan untuk mengukur rasionalitas penggunaan antibiotik. Penelitian ini dilakukan di RSUD Meuraxa Provinsi Aceh menggunakan metode deskriptif evaluatif dengan desain cross-sectional. pengambilan data dilakukan secara retrospektif dari rekam medik periode Januari-Desember 2022. Sampel yang digunakan berjumlah 80 data rekam medik dengan teknik pengambilan Proportionate Stratified Random Sampling. Hasil dari penelitian didapatkan 32 (34.78%) pasien dengan Respiratory Disorder. Digunakan 140 antibiotik; terdiri dari 138 (98.57%) empiris dan 2 (1.43%) definitif. Ceftriaxone merupakan antibiotik paling banyak digunakan (39.29%). Berdasarkan metode Gyssens, penggunaan antibiotik tepat (kategori 0) sebanyak 44.29%, sedangkan tidak tepat, yaitu 21.43% kategori VI (data tidak lengkap), 14.29% kategori IVA (alternatif lebih efektif), 1.43% kategori IVB (alternatif lebih aman), 1.43% kategori IVC (alternatif lebih murah), 6.43% kategori IIIA (durasi terlalu panjang), 1.43% kategori IIIB (durasi terlalu singkat), 2.86% kategori IIA (dosis tidak tepat), 5.00% kategori IIB (interval tidak tepat) dan 1.43% kategori I (timing tidak tepat). Kesimpulan dari penelitian ini penggunaan antibiotik masih rendah, dimana ≤50% penggunaan antibiotik masuk dalam kategori 0 (rasional).

ICU patients frequently suffer from infections. Antibiotics are one of the treatments for infections. Antibiotic resistance is contributed to by inappropriate antibiotic use. The Gyssens method was utilized to assess the rationality of antibiotic use. This cross-sectional study was conducted at Meuraxa Hospital in Aceh Province using a descriptive evaluation method. For the period of January to December 2022, data were gathered retrospectively from medical records. Using the technique of Proportional Stratified Random Sampling, a sample of 80 medical record data was collected. The study found that 32 patients (34.78%) had a Respiratory Disorder. 140 antibiotics were utilized, with 138 (98.57%) being empirical and 2 (1.43%) being definitive. Ceftriaxone was the most commonly used antibiotic (39.29% of all antibiotics). According to the Gyssens method, the use of appropriate antibiotics (category 0) was 44.29%, while the use of inappropriate antibiotics, namely 21.43% category VI (incomplete data), 14.29% category IVA (alternative is more effective), 1.43% category IVB (alternative is less toxic), 1.43% category IVC (cheaper alternative), 6.43% category IIIA (excessively long duration), 1.43% category IIIB (insufficient duration), 2.86% category IIA (dosage not appropriate), 5.00% category IIB (interval not appropriate) and 1.43% category I (time not appropriate). The study's findings indicate that the utilization of antibiotics remains limited, with less than or equal to 50% of antibiotic usage falling within the sensible group (category 0).