Electronic Theses and Dissertation

Chronic Kidney Disease (CKD) merupakan kerusakan ginjal dengan adanya penurunan Laju Filtrasi Glomerulus (LFG) kurang dari 60 mL/menit/1,73 m2 selama minimal 3 bulan. Nilai LFG di bawah 15 mL/menit/1,73 m2 merupakan penanda seseorang telah terindentifikasi gagal ginjal kronis stadium akhir atau End Stage Renal Disease (ESRD). Terapi CKD stadium akhir yang paling banyak digunakan yaitu terapi hemodialisis. Penggunaan antibiotik harus dipertimbangkan karena beberapa antibiotik bersifat toksik terhadap ginjal. Pengobatan gagal ginjal kronik dengan terapi antibiotik yang tepat dan rasional akan menentukan keberhasilan pengobatan. Penggunaan antibiotik yang rasional dapat dilihat dari beberapa parameter, yaitu tepat obat, tepat dosis dan frekuensi, dan tepat waktu pemberian. Penelitian ini bertujuan mengetahui profil penggunaan dan evaluasi tepat obat, tepat dosis dan frekuensi, serta tepat waktu pemberian penggunaan antibiotik pada pasien Chronic Kidney Disease yang menjalani hemodialisis di Ruang Rawat Inap Penyakit Dalam RSUD Zainoel Abidin. Penelitian dilakukan menggunakan metode cross-sectional dan dilakukan secara prospektif. Sampel penelitian ini yaitu sebanyak 60 pasien yang telah memenuhi kriteria inklusi dan eksklusi. Data dikalkulasikan dalam bentuk persentase dan dianalisis dengan menggunakan teknik analisis univariat. Hasil penelitian menunjukkan evaluasi penggunaan antibiotik berdasarkan kriteria tepat obat yaitu 100%, tepat dosis dan frekuensi yaitu 68,33%, serta tepat waktu pemberian yaitu 93,33%.

Chronic Kidney Disease (CKD) is kidney damage with a decrease in Glomerular Filtration Rate (GFR) of less than 60 mL/min/1.73 m2 for at least 3 months. GFR value below 15 mL/minute/1.73 m2 is a marker for someone who has been identified with end-stage chronic kidney disease or End Stage Renal Disease (ESRD). The most widely used CKD end stage therapy is hemodialysis therapy. The use of antibiotics must be considered because some antibiotics are toxic to the kidneys. Treatment of Chronic Kidney Disease with appropriate and rational antibiotic therapy will determine the success of treatment. Rational use of antibiotics can be seen from several parameters, namely the right drug, the right dose and frequency, and the right time of administration. This study aims to determine the profile of the use and evaluation of the right drug, the right and frequency, and the right time of administration of antibiotic use in Chronic Kidney Disease patients undergoing hemodialisis in the Internal Medicine Inpatient Room at Zainoel Abidin Hospital. The study was conducted using a cross-sectional method and conducted prospectively. The sample of this study was 60 patients who met the inclusion and exclusion criteria. Data were calculated into percentages and analyzed using univariate analysis techniques. The results showed that the evaluation of antibiotic use based on the right drug criteria was 100%, the right dose and frequency was 68.33%, and the right time of administration was 93.33%.