Electronic Theses and Dissertation

Penelitian ini bertujuan untuk mengetahui potensi gastroprotektor ekstrak etanol kulit batang bau langit Cyathocalyx sumatranus (EEKBCS) terhadap struktur histologis lambung tikus (Rattus norvegicus Berkenhout.) yang diinduksi parasetamol. Penelitian ini menggunakan metode eksperimental. Analisis data menggunakan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 5 ulangan. Perlakuan terdiri atas pemberian akuades (K0), induksi parasetamol dan akuades (K-), induksi ekstrak etanol kulit batang C. sumatranus (EEKBCS) (150 mg/kgBB) (P1), 300 mg/kgBB (P2), dan 600 mg/kgBB (P3). Parasetamol (1.350 mg/kgBB) diberikan pada hari ke-7 perlakuan secara oral untuk seluruh perlakuan (kecuali K0). Lambung hewan uji dijadikan sediaan histologis dengan metode parafin serta pewarnaan hematoksilin-eosin (HE). Parameter yang diamati adalah tingkat kerusakan mukosa lambung berupa deskuamasi, erosi, dan ulserasi. Data penelitian dianalisis menggunakan Kruskall-Wallis dan dilanjutkan dengan uji Mann-Whitney. Hasil penelitian menunjukkan bahwa terdapat pengaruh pemberian EEKBCS terhadap struktur histologis lambung tikus. Berdasarkan hasil penelitian disimpulkan bahwa dosis 300 mg/kgBB dan 600 mg/kgBB EEKBCS memiliki potensi sebagai gastroprotektor.
Kata kunci: Cyathocalyx sumatranus, parasetamol, deskuamasi, erosi, ulserasi, mukosa lambung

This research aims to determine the gastroprotector potency of the ethanol extract of the stem bark of Cyathocalyx sumatranus (EESBCS) on the histological structure of the stomach of rats (Rattus norvegicus Berkenhout.) induced by paracetamol. This research uses an experimental method. Data analysis used a Completely Randomized Design (CRD) with five treatments and five replications. The treatment consisted of administration of distilled water (K0), induction of paracetamol and distilled water (K-) and external induction of ethanol from the stem bark of C. sumatranus (EESBCS) (150 mg/kgBW) (treatment 1), 300 mg/kgBW (treatment 2), and 600 mg/kgBW (treatment 3). Paracetamol (1.350 mg/kgBW) was given on the 7th day of oral treatment for all treatments (except K0). The stomachs of the test animals were made into histological preparations using the paraffin method and stained with hematoxylin -eosin (HE). Parameters observed were the level of damage to the gastric mucosa in the form of desquamation, erosion, and ulceration. The research data were analyzed using Kruskall-Wallis and continued with Mann Whitney test. The results showed that there was an effect of EESBCS administration on the histological structure of the rat stomach. Based on the results of the research, it was concluded that a dose of 300 mg/kgBW and 600 mg/kgBW EESBCS has potential as a gastroprotector. Keywords: Cyathocalyx sumatranus, paracetamol, desquamation, erosion, ulceration, gastric mucosa.