Electronic Theses and Dissertation

Daun kari memiliki kandungan antioksidan yang tinggi dan diyakini memiliki potensi sebagai obat herbal dalam terapi penyakit, termasuk tumor. Daun kari mengandung zat aktif seperti alkaloid, tanin, flavonoid, dan fenolik. Penelitian ini bertujuan untuk mengevaluasi gambaran histopatologi hati tikus (Sprague Dawley) setelah diberikan terapi ekstrak etanol daun kari pada tumor mammae. Sebanyak 9 ekor tikus betina dengan bobot badan 150-200 gram digunakan sebagai subjek penelitian dan dibagi secara acak menjadi 3 kelompok perlakuan. Kelompok kontrol diberi air destilasi. Kelompok perlakuan I diberi ekstrak daun kari dengan dosis 300 mg/kg BB, dan Kelompok perlakuan II diberi ekstrak daun kari dengan dosis 400 mg/kg BB. Pemberian ekstrak daun kari dilakukan selama 30 hari pada pagi hari. Data yang diperoleh dianalisis secara deskriptif. Hasil pengamatan histopatologi memperlihatkan bahwa pemberian ekstrak daun kari dengan dosis 300 mg/kgBB dan 400 mg/kgBB mengakibatkan perubahan sel ringan pada organ hati berupa degenerasi sel, kongesti, inflamasi dan nekrosis. Berdasarkan hasil yang diperoleh ekstrak daun kari aman digunakan sebagai obat herbal anti tumor.

Curry leaves have high antioxidant content and are believed to have potential as herbal medicines in the treatment of diseases, including tumors. Curry leaves contain active substances such as alkaloids, tannins, flavonoids and phenolics. This study aims to evaluate the liver histopathology of rats (Sprague Dawley) after being treated with ethanol extract of curry leaves on mammary tumors. Nine female rats with body weight of 150-200 grams were used as research subjects and randomly divided into 3 treatment groups. The control group was given distilled water, the first treatment group was given curry leaf extract at a dose of 300 mg/kg, and the second treatment group was given curry leaf extract at a dose of 400 mg/kg. Curry leaf extract was administered for 30 days in the morning. The data obtained were analyzed descriptively. The results of the study after histopathological observation showed that administration of curry leaf extract at doses of 300 mg/kg and 400 mg/kg resulted in mild cell changes in the liver in the form of cell degeneration, congestion, inflammation and necrosis. Based on the results obtained, curry leaf extract is safe to use as an anti-tumor herbal medicine.