Electronic Theses and Dissertation

ABSTRAK
HUBUNGAN TGF-β1 URIN TERHADAP DERAJAT PROTEINURIA 24 JAM DAN LAJU FILTRASI GLOMERULUS PADA PASIEN NEFRITIS LUPUS

Latar Belakang
Sebanyak 60% pasien LES dewasa akan mengalami komplikasi ginjal. Meskipun telah ada kemajuan dalam diagnosis dan pengobatan, namun >20% pasien dengan LN berkembang menjadi PGK dalam waktu 15 tahun sejak diagnosis awal. TGF-β1 berfungsi sebagai mediator penting dari akumulasi matriks ekstraseluler, fibrosis glomerulus, dan proliferasi sel mesangial. Penelitian ini bertujuan untuk melihat hubungan antara TGF-β1 urin dengan derajat proteinuria 24 jam dan laju filtrasi glomerulus sebagai salah satu penanda kerusakan ginjal.

Metode
Penelitian ini berupa cross sectional. Sampel penelitian adalah penderita nefritis lupus dewasa di RSUD dr. Zainoel Abidin Banda Aceh periode September s/d November 2022. Data karakteristik diambil dari rekam medik. Sebanyak 26 sampel dilakukan pemeriksaan TGF-β1 urin dan proteinuria 24 jam serta perhitungan laju filtrasi glomerulus. Uji Pearson untuk menilai korelasi dilakukan pada penelitian ini.

Hasil
Nilai median TGF-B1 urin pada pasien nefritis lupus adalah 11,15 pg/ml dengan kisaran 5,99-452,05 pg/ml. Didapatkan hubungan yang signifikan antara TGF-β1 urin terhadap derajat proteinuria 24 jam dengan p value 0,02 dengan korelasi sedang. Kadar TGF-β1 urin berkorelasi negatif terhadap LFG namun tidak berhubungan signifikan secara statistik dengan p value 0,07.

Kesimpulan
Terdapat hubungan yang signifikan antara kadar TGF-β1 urin dengan derajat proteinuria 24 jam namun hubungan antara kadar TGF-β1 urin dengan LFG tidak signifikan secara statistik.

Kata Kunci
TGF-β1 urin, nefritis lupus, proteinuria, LFG

ABSTRACT RELATIONSHIP BETWEEN URINARY TGF-β1 TO 24-HOUR PROTEINURIA DEGREE AND GLOMERULUS FILTRATION RATE IN LUPUS NEPHRITIS PATIENTS Background Approximately 60% of adult SLE patients will experience renal complications. Despite advances in diagnosis and treatment, >20% of patients with LN develop CKD within 15 years of initial diagnosis. TGF-β1 functions as an important mediator of extracellular matrix accumulation, glomerular fibrosis, and mesangial cell proliferation. This study aims to examine the relationship between urinary TGF-β1 with the degree of proteinuria at 24 hours and glomerular filtration rate as a marker of kidney damage. Method This research is a cross sectional study. The research sample was adult lupus nephritis sufferers at dr. Zainoel Abidin Banda Aceh for the period September to November 2022. Characteristic data was taken from medical records. A total of 26 samples were examined for urine TGF-β1 and 24-hour proteinuria and calculation of glomerular filtration rate. The Pearson test to assess correlation was carried out in this study. Results The median value of urinary TGF-B1 in patients with lupus nephritis was 11.15 pg/ml with a range of 5.99-452.05 pg/ml. A significant relationship was found between urinary TGF-β1 and the degree of proteinuria at 24 hours as indicated by a p value 0.02, with a moderate correlation. Urinary TGF-β1 levels have a negative correlation with GFR but not statistically significant as indicated by a p value 0.07. Conclusion There was a significant relationship between urinary TGF-β1 levels and the degree of proteinuria at 24 hours but the relationship between urinary TGF-β1 levels and GFR was not statistically significant. Keywords Urinary TGF-β1, lupus nephritis, proteinuria, GFR