Electronic Theses and Dissertation

Pendahuluan: Helicobacter pylori (H. pylori) merupakan salah satu penyebab dalam perburukan lesi mukosa gastroduodenal. Peran H. pylori dalam patogenesis lesi gastroduodenal yang disebabkan obat anti inflamasi non steroid (OAINS) belum banyak dikaji. Beberapa laporan penelitian menyiratkan terdapat pengaruh sinergis H. pylori pada gastropati yang diinduksi OAINS, serta temuan 25 s.d. 76% pasien autoimun diobati dengan OAINS, akibatnya memiliki risiko tinggi cedera mukosa gastroduodenal. Namun korelasi antara H. pylori, lesi gastroduodenal, serta penggunaan OAINS, terkhusus pada pasien gangguan autoimun, masih kurang diteliti. Penelitian ini bertujuan untuk mengetahui hubungan antara penggunaan OAINS dengan kejadian infeksi H. Pylori.
Metode: Penelitian ini bersifat analitik observasional dengan desain potong lintang yang dilakukan di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh dari bulan Juli hingga Desember 2022. Infeksi positif H. pylori diukur dengan pemeriksaan Urea Breath Test (UBT) dan Helicobacter Pylori Stool Antigen (HPSA). Hubungan antara kedua variabel dianalisis menggunakan uji Pearson Chi-square dengan interval kepercayaan 95%.
Hasil: Responden terbanyak berjenis kelamin peremupan (93,3%), pada rentang usia 18 – 44 tahun (86,6%), dengan penyakit autoimun Systemic Lupus Erythematosus (SLE) (56,6%), Rheumatoid Arthritis (RA) (26,6%), serta SLE dan RA (16,6%). Terapi yang diperoleh meliputi Disease Modifying Anti Rheumatic Drugs (DMARD), OAINS, dan kortikosteroid (43,3%), DMARD dan kortikosteroid (30%), serta DMARD dan OAINS (26,6%). Temuan positif H. pylori tampak dari pemeriksaan UBT (40%), HPSA (3,3%), dan UBT serta HPSA (3,3%). Tingginya persentase kejadian infeksi H. pylori pada responden penyakit autoimun yang mengkonsumsi OAINS pada penelitian ini, namun tidak memiliki hubungan signifikan dari analisis statistik.
Kesimpulan: Tidak dijumpai hubungan pengunaan OAINS dengan kejadian infeksi H. pylori yang dibuktikan dengan pemeriksaan UBT, HPSA, serta UBT dan HPSA

Kata kunci: helicobacter pylori, OAINS, UBT, HPSA

Introduction: Helicobacter pylori (H. pylori) is one of the causes of exacerbation of gastroduodenal mucosal lesions. The role of H. pylori in the pathogenesis of gastroduodenal lesions caused by non-steroidal anti-inflammatory drugs (NSAIDs) has not been widely studied. Several research reports suggest there is a synergistic effect of H. pylori on NSAID-induced gastropathy, as well as findings 25 s.d. 76% of autoimmune patients treated with NSAIDs, consequently have a high risk of injury to the gastroduodenal mucosa. However, the correlation between H. pylori, gastroduodenal lesions, and the use of NSAIDs, especially in patients with autoimmune disorders, is still lacking in research. This study aims to determine the relationship between the use of NSAIDs and the incidence of H. Pylori infection. Methods: This is an observational analytic study with a cross-sectional design conducted at the Regional General Hospital dr. Zainoel Abidin Banda Aceh from July to December 2022. Positive H. pylori infection was measured by Urea Breath Test (UBT) and Helicobacter Pylori Stool Antigen (HPSA) examinations. The relationship between the two variables was analyzed using the Pearson Chi-square test with 95% confidence intervals. Results: Most respondents were female (93.3%), in the age range 18-44 years (86.6%), with Systemic Lupus Erythematosus (SLE) (56.6%), Rheumatoid Arthritis (RA) ( 26.6%), SLE and RA (16.6%). The therapies obtained included Disease Modifying Anti Rheumatic Drugs (DMARD), NSAIDS and corticosteroids (43.3%), DMARD and corticosteroids (30%), and DMARD and NSAIDs (26.6%). Positive H. pylori findings were seen from UBT (40%), HPSA (3.3%), and UBT and HPSA (3.3%) examinations. The high percentage of H. pylori infection in autoimmune disease responders who consumed NSAIDs in this study, however, did not have a significant relationship from statistical analysis. Conclusion: There was no relationship between the use of NSAIDs and the incidence of H. pylori infection as evidenced by UBT, HPSA, and UBT and HPSA examinations. Keywords: helicobacter pylori, NSAIDS, UBT, HPSA