Electronic Theses and Dissertation

Leukimia granulositik kronik merupakan jenis penyakit mieloproliferatif dengan translokasi kromosom yang dikenal sebagai kromosom philadelphia. Penyakit ini memiliki banyak terapi salah satunya tyrosine kinase inhibitor. Tyrosine kinase inhibitor mencegah pengaktifan protein breakpoint cluster gene-abelson murine yang dihasilkan kromosom philadelphia. Penelitian ini bertujuan untuk mengetahui karakteristik penderita leukimia granulositik kronik di bagian/SMF Rumah Sakit dr.Zainal Abidin Banda aceh. Penelitian ini dilakukan di RSUD dr. Zainoel Abidin Banda Aceh pada 31 responden dengan rancangan penelitian deskriptif menggunakan metode cross sectional. Kriteria responden pada penelitian ini adalah pasien positif breakpoint cluster gene-abelson murine. Hasil penelitian ini mendeskripsikan karateristik pasien LGK berdasarkan jenis kelamin, asal daerah, pekerjaan, umur, profil hematologi, dan pemeriksaan limpa. Hasil pada penelitian ini di dapat mayoritas dari pasien LGK berjenis kelamin laki-laki dengan persentase 51,61%, mayoritas rentang umur 36-45 tahun dengan persentase 35,48%, pekerjan pasien mayoritas adalah petani dengann persentase 35,48%,mayoritas pasien berasal dari kabupaten bireun dengan persentase 35,48%, 100% pasien mengalami pembesaran limpa dengan 32,25% pasien mengalami pembesaran sampai schuffner VI, serta profil hematologi sebagai berikut; anemia 96,77%, leukositosis 87,09%, 35,48% trombositosis, basofilia 74,19%, peningkatan hitung jenis neutrofil segmen pada 90,32% pasien, penurunan neurofil batang pada 93,54% pasien, serta penurunan limfosit pada 90,32% pasien.
Kata kunci: LGK, profil hematologi, pemeriksaan limpa, Tyrosine kinase inhibitor, kromosom Philadelphia

Chronic myeloid leukemia is a type of myeloproliferative disease with a chromosomal translocation known as the Philadelphia chromosome. This disease has many therapies, one of which is tyrosine kinase inhibitors. Tyrosine kinase inhibitors prevent activation of the murine Gene-Abelson cluster protein breakpoint cluster produced by the Philadelphia chromosome. This study aims to determine the characteristics of patients with chronic granulocytic leukemia in the department/SMF of Dr. Zainal Abidin Hospital, Banda Aceh. This research was conducted at dr. Zainoel Abidin Banda Aceh on 31 respondents with a descriptive research design using a cross sectional method. Respondent criteria in this study were positive breakpoint cluster gene-abelson murine patients. The results of this study describe the characteristics of LGK patients based on gender, region of origin, occupation, age, hematological profile, and spleen examination. The results in this study showed that the majority of LGK patients were male with a proportion of 51.61%, the majority aged 36-45 years with a proportion of 35.48%, the majority of patients were farmers with a proportion of 35.48%, the majority of patients came from the district of Bireuen with a proportion of 35.48%, 100% of the patients had an enlarged spleen with 32.25% of the patients had an enlarged up to Schuffner VI, and the hematological profile was as follows; anemia 96.77%, leukocytosis 87.09%, thrombocytosis 35.48%, basophilia 74.19%, increased segment neutrophil count in 90.32% of patients, decreased neurophilic stem in 93.54% of patients, and decreased lymphocytes in 90.32% of patients. Keywords: CML, hemathological profile, spleen examination, thyrosine kinase inhibitor, Philadelphian chromosome