Electronic Theses and Dissertation

Pendahuluan: Central post stroke pain (CPSP) adalah sebuah sindrom nyeri neuropatik yang terjadi setelah serangan stroke. CPSP dapat terjadi pasca stroke iskemik maupun stroke hemoragik dengan prevalensi 1-35%. CPSP dikaitkan dengan lokasi lesi pada thalamus, namun dapat pula muncul pada lesi ekstrathalamus dan korteks. Metodologi: Penelitian ini merupakan studi observasional dengan desain cross sectional untuk menilai perbandingan letak dan jenis stroke terhadap kejadian dan derajat nyeri CPSP pada pasien post-stroke. Sampel penelitian ini merupakan seluruh pasien post stroke yang di konfirmasi dengan Computed Tomography ( CT Scan) kepala, onset minimal  28 hari sampai 180 hari. Kemudian dinilai lokasi dan jenis stroke berdasarkan CT-Scan. Dilakukan skrining komponen nyeri neuropatik dengan Neuropathic Pain Questionnaire (DN4) dan derajat nyeri dengan Numeric Rating Scale (NRS). Hasil Penelitian: Sebanyak 65 sampel penelitian yang memenuhi kriteria inklusi ekslusi dan bersedia menjadi subjek penelitian. Berdasarkan uji statistik menggunakan uji chi-square didapatkan letak lesi berhubungan kuat dengan kejadian CPSP dan derajat nyeri CPSP (p0.05). Hal ini sesuai dengan gejala klinis pasien, dimana pasien dengan CPSP selalu mengalami defisit suhu dan sensibilitas nyeri yang menunjukkan lesi pada traktus spinotalamikus, terutama melibatkan thalamus dan proyeksi nya. Kesimpulan: Letak lesi stroke berhubungan dengan kejadian CPSP dan derajat nyeri pada pasien CPSP, dimana yang paling berhubungan adalah lesi yang terdapat di Thalamus.

Kata Kunci : Central post stroke pain, Post Stroke Pain, Nyeri Neuropatik, Stroke iskemik, Stroke Hemoragik.

Introduction: Central post stroke pain (CPSP) is a neuropathic pain syndrome that occurs after a stroke. CPSP can occur after ischemic stroke or hemorrhagic stroke with a prevalence of 1-35%. CPSP is associated with the location of the lesion in the thalamus, but can also occur in extrathalamic and cortex lesions. Methodology: This study was an observational study with a cross-sectional design to assess the comparative location and type of stroke to the incidence and degree of CPSP pain in post-stroke patients. The sample of this study were all post stroke patients confirmed by Computed Tomography with a minimum onset of 28 days to 180 days. Then assess the location and type of stroke based on the CT-Scan. The neuropathic pain component was screened with the Neuropathic Pain Questionnaire (DN4) and the degree of pain with the Numeric Rating Scale (NRS). Results: A total of 65 research samples met the inclusion and exclusion criteria and were willing to become research subjects. Based on statistical tests using the chi-square test, it was found that the location of the lesion was strongly associated with the incidence of CPSP and the degree of CPSP pain (p0.05). This is consistent with the patient's clinical symptoms, where patients with CPSP always experience a deficit in temperature and pain sensibility which indicates a lesion in the spinothalamic tract, especially involving the thalamus and its projections. Conclusion: The location of the stroke lesion is related to the incidence of CPSP and the degree of pain in CPSP patients, where the lesion in the thalamus is the most related. Keywords: Central post stroke pain, Post Stroke Pain, Neuropathyc Pain, Stroke Ischemic, Stroke Hemoraghic.