Electronic Theses and Dissertation

Neuropati diabetik merupakan salah satu komplikasi kronis paling sering ditemukan pada
diabetes melitus. Patogenesis terjadinya nyeri neuropati diabetik merupakan
kombinasi degenerasi dan demielinisasi aksonal. Citicoline memiliki beberapa
mekanisme neuroprotector, dapat mempertahankan integritas membran sel neuron yang
rusak. Penelitian ini menganalisis skala nyeri, kecepatan hantar saraf, dan skala
kualitas hidup pada pasien neuropati diabetik yang diberikan citicoline dan
kontrol. Penelitian adalah penelitian quasi-experimental dengan desain non
equivalent control group design, dengan metode single blind. Populasi dalam
penelitian ini adalah pasien neuropati diabetik di RSUD dr. Zainoel Abidin Banda
Aceh dan menggunakan metode simple random sampling. Analisis data
menggunakan uji T independent untuk data berdistribusi normal dan uji Mann
Whitney untuk yang tidak berdistribusi normal. Hasil penelitian menunjukkan
terdapat 60 pasien yang menjadi sampel penelitian, dibagi menjadi 2 kelompok,
perlakuan dan kontrol. Selisih rerata skor NRS setelah perlakuan menunjukkan
perbedaan yang signifikan, hasil Uji Mann-Whitney, p-value = 0,047. Selisih
rerata nilai KHS setelah perlakuan menunjukkan perbedaan yang signifikan, hasil
Uji T Independen, p-value = 0,001 . Selisih rerata skor EQ-5D setelah perlakuan
menunjukkan perbedaan yang signifikan, hasil Uji Mann-Whitney, p-value =
0,005. Kesimpulan dari penelitian ini adalah terdapat perbedaan perbaikan skala
nyeri neuropati, kecepatan hantar saraf, dan peningkatan kualitas hidup yang
signifikan pada pasien neuropati diabetik yang diberikan citicoline dibandingkan
dengan kontrol.

Kata Kunci: Neuropati diabetik, Citicoline, Skala Nyeri, Kecepatan Hantar Saraf,
Kualitas Hidup

Diabetic neuropathy is one of the most common chronic complications in diabetes mellitus. The pathogenesis of diabetic neuropathic pain is a combination of axial degeneration and demyelination. Citicoline has several neuroprotective mechanisms, it can maintain the integrity of damaged neuron cell membranes. This study analyzed the pain scale, nerve conduction velocity, and quality of life scale in diabetic neuropathy patients who were given citicoline and controls. This is a quasi-experimental study with non equivalent control group design, and used single blind method. the population in this study were diabetic neuropathy patients at RSUDZA Banda Aceh and using simple random sampling method. Data analysis used independent T test for data with normal distribution and Mann Whitney test for non-normally distributed data. The results showed that there were 60 patients as the sample of the study, divided into 2 groups, treatment and control. The difference in the mean NRS scores showing a significant difference, the results of the Mann-Whitney Test, p-value = 0.047. The difference in the mean KHS value showing a significant difference, the results of the Independent T Test, p value = 0.001. The difference in the mean scores of EQ-5D showed a significant difference, the results of the Mann-Whitney test, p-value = 0.005. This study concluded that there were significant differences in the improvement of the neuropathy scale, nerve conduction velocity, and a significant improvement in quality of life in diabetic neuropathy patients who were given citicoline compared to controls. Keywords: Diabetic neuropathy, Citicoline, Pain Scale, Nerve Conduction Velocity, Quality of Life