Electronic Theses and Dissertation

Latar Belakang: Gangguan kognitif merupakan salah satu gejala jangka panjang yang bertahan pada pasien COVID-19 setelah melewati fase akut yang dapat berdampak negatif pada fungsional individu. Gangguan kognitif pada post COVID- 19 banyak dihubungkan dengan keparahan pasien pada fase akut. Kadar D-dimer sering digunakan sebagai biomarker keparahan COVID-19 pada fase akut. Tujuan: Untuk mengetahui hubungan kadar D-Dimer dengan fungsi kognitif pada pasien post COVID-19. Metode: Penelitian analitik observasional dengan menggunakan desain cross sectional di Rumah Sakit Umum Dr. Zainoel Abidin, dengan mengumpulkan data D-Dimer pasien COVID-19 rawat inap pada Agustus-Oktober 2021, kemudian dilakukan pemeriksaan fungsi kognitif menggunakan kuesioner Moca-Ina setelah > 6 bulan melewati fase akut. Hasil: Responden pada penelitian ini dominan jenis kelamin perempuan dan kelompok usia 36-45 tahun. Hasil penelitian ini didapatkan lebih banyak responden dengan peningkatan kadar D- Dimer pada fase akut (74,1%), dan ditemukan fungsi kognitif yang terganggu lebih dominan (72,9%), serta terdapat hubungan yang kuat antara kadar D-dimer dengan fungsi kognitif pasien post COVID-19 (r = 0,849). Kesimpulan: Terdapat hubungan yang signifikan dan berkorelasi kuat antara kadar D-Dimer pada fase akut COVID- 19 dengan gangguan fungsi kognitif pada pasien post COVID-19.
Kata Kunci: D-Dimer, Fungsi Kognitif, Moca-Ina, Post COVID-19

Background: Cognitive impairment is one of the long-term symptoms that persist in COVID-19 patients after passing through the acute phase which can have a negatively affect functional outcomes. Cognitive impairment in post-COVID-19 is widely associated with the severity of the patient in the acute phase. D-dimer levels are often used as a biomarker of the severity of COVID-19 in the acute phase. Objective: To determine the relationship between D-Dimer levels and cognitive function in post-COVID-19 patients. Methods: An observational analytic study using a cross sectional design at Dr. Zainoel Abidin General Hospital, by collecting D-Dimer data on hospitalized COVID-19 patients in August-October 2021, then carried out a cognitive function examination by Moca-Ina questionnaire after > 6 months through the acute phase. Results: Respondents in this study were predominantly female and the age group was 36-45 years old. Our study were found that more respondents with increased levels of D-Dimer in the acute phase (74,1%), and found that impaired cognitive function is more dominant (72,9%), there is also a strong relationship between D-dimer levels and cognitive function in post- COVID-19 patients (r = 0,849). Conclusion: There is a significant and strongly correlated relationship between D-Dimer levels in the acute phase of COVID-19 with impaired cognitive function in post-COVID-19 patients. Keywords: Cognitive Function, D-Dimer, post COVID-19, Moca-Ina