Electronic Theses and Dissertation

Isolasi minyak atsiri bunga tanjung (Mimusops elengi L.) dilakukan dengan metode enfleurasi, dan minyak atsiri diformulasikan menjadi sediaan gel, kemudian diuji aktivitasnya terhadap bakteri P. acnes menggunakan metode difusi cakram agar. Hasil penelitian menunjukkan bahwa minyak berwarna kuning jernih dengan rendemen sebesar 4,39%, berat jenis 0,964 g/mL, indeks bias 1,435, dan kelarutan dalam alkohol 1:2 jernih yang memenuhi syarat sebagai minyak esensial. Nilai daya hambat gel lebih tinggi dibandingkan minyak atsiri yaitu 57% untuk daya hambat tertinggi gel dengan konsentrasi 2,5%, dan 52% untuk daya hambat minyak atsiri dengan konsentrasi 2,5%. Hasil uji sifat fisik gel menunjukkan bahwa sediaan semi padat dengan nilai pH berada pada kisaran 5,97-7,00 dan nilai viskositas berada pada kisaran 2190-4851,3 Cp. Nilai pH dan nilai viskositas yang diperoleh telah sesuai dengan standar Nasional Indonesia. Nilai daya sebar berada pada kisaran 2,6-5,8 cm dan nilai daya lekat pada kisaran 6,78-13,26 detik yang stabil dalam warna, bau, dan tekstur pada 4 minggu pengamatan. Hasil karakterisasi GC-MS minyak atsiri bunga tanjung (M. elengi L.) mengandung 54 senyawa dengan senyawa yang dominan adalah delta-elemene (14.32%), bycyclogermacrene (9.77%), and trans-geraniol (9.28%).

Kata kunci: Mimusops elengi L., enfleurasi, antibakteri, acne, gel

Isolation of the essential oil of tanjung (Mimusops elengi L.) flower was carried out by enfleuration method, and the essential oil was formulated into a gel preparation, then its activity was tested against P. acnes bacteria using the agar disk diffusion method. The results showed that the oil was clear white with a yield of 4,39%. Specific gravity 0,964 g/mL, Refractive index 1,435, Solubility in alcohol 1:2 clear, which qualifies as essential oil. The inhibitory value of gel was higher than that of essential oil, namely 57% for the highest inhibitory power of the gel with a concentration of 2,5%, and 52% for the inhibitory power of essential oil, with a concentration of 2,5%. The results of the physical properties test of the gel showed that the semi-solid preparation with a pH value was in the range 5,97-7,00 and the viscosity value was in the range 2190-4851,3 Cp. The pH value and viscosity value obtained are in accordance with Indonesian National standards. The value of dispersion is in the range of 2,6-5,8 cm and the value of adhesion is in the range of 6,78-13,26 seconds, stable in color, smell, and texture, at 4 weeks of observation. The results of characterization by GC-MS extract of tanjung (M. elengi L.) flower essential oil contained 54 compounds, and the dominant was delta-elemene (14.32%), bycyclogermacrene (9.77%), and trans-geraniol (9.28%). Keywords: Mimusops elengi L., enfleurage, antibacterial, acne, gel