Electronic Theses and Dissertation

Burkholderia merupakan salah satu bakteri patogen yang menginfeksi manusia. Tujuan dari penelitian ini untuk mengetahui prevalensi, distribusi Burkholderia cepacia berdasarkan jenis spesimen, usia dan jenis kelamin pasien, ruang rawat di RSUD dr. Zainoel Abidin Banda Aceh, serta mengetahui pola kepekaan antibiotik terhadap Burkholderia cepacia dari spesimen klinis periode Maret 2019-Maret 2022. Penelitian ini menggunakan metode deskriptif yaitu dengan melakukan isolasi, identifikasi, dan uji kepekaan Burkholderia cepacia terhadap antibiotik yang diisolasi dari spesimen klinis RSUD dr. Zainoel Abidin Banda Aceh. Hasil penelitian ini menunjukkan Burkholderia cepacia yang diperoleh dari spesimen klinis adalah sebanyak 127 isolat. Prevalensi paling tinggi ditemukan pada spesimen CVC (Central Venous Catheters) dan swab yaitu terdapat 7 spesimen positif terinfeksi Burkholderia cepacia dari jumlah total 86 spesimen dengan persentase 8,13%. Prevalensi paling rendah ditemukan pada spesimen sputum dan ETT (Endotracheal tube) yaitu terdapat 8 spesimen positif terinfeksi Burkholderia cepacia dari jumlah total 2126 spesimen dengan persentase 0.37%. Distribusi Burkholderia cepacia berdasarkan jenis spesimen paling banyak ditemukan pada spesimen darah dan cairan steril 70 spesimen (55.11%). Distribusi Burkholderia cepacia berdasarkan usia paling banyak ditemukan pada pasien berusia 46-55 tahun sebanyak 37 orang (29.13%) dan berdasarkan jenis kelamin paling banyak ditemukan pada laki-laki sebanyak 75 orang (59.05%). Distribusi Burkholderia cepacia berdasarkan ruang rawat paling banyak ditemukan pada Ruang Penyakit Dalam sebanyak 35 spesimen (27.5%). Kepekaan antibiotik Burkholderia cepacia paling tinggi pada Ceftazidime sebesar 92.7%, sehingga antibiotik Ceftazidime paling efektif digunakan untuk mengatasi infeksi yang disebabkan Burkholderia cepacia.

Kata kunci: antibiotik, Burkholderia cepacia, distribusi, spesimen klinis

Burkholderia is one of the pathogenic bacteria that infect humans. The purpose of this study was to determine the prevalence, distribution of Burkholderia cepacia based on the type of specimen, age and gender of the patient, ward at RSUD dr. Zainoel Abidin Banda Aceh, as well as knowing the pattern of antibiotic susceptibility to Burkholderia cepacia from clinical specimens for the period March 2019-March 2022. This study used a descriptive method by isolating, identifying, and testing the sensitivity of Burkholderia cepacia to antibiotics isolated from clinical specimens of RSUD dr. Zainoel Abidin Banda Aceh. The results of this study showed that there were 127 isolates of Burkholderia cepacia obtained from clinical specimens. The highest prevalence was found in CVC (Central Venous Catheters) and swabs, namely there were 7 specimens positive for Burkholderia cepacia infection from a total of 86 specimens with a percentage of 8.13%. The lowest prevalence was found in sputum specimens and ETT (Endotracheal tube), namely there were 8 positive specimens infected with Burkholderia cepacia from a total of 2126 specimens with a percentage of 0.37%. Distribution of Burkholderia cepacia by type of specimen was most commonly found in blood and sterile fluid specimens of 70 specimens (55.11%). The distribution of Burkholderia cepacia based on age was most commonly found in patients aged 46-55 years as many as 37 people (29.13%), and based on gender the most were found in males as many as 75 people (59.05%). The distribution of Burkholderia cepacia based on the ward was mostly found in the Internal Medicine Room with 35 specimens (27.5%). Burkholderia cepacia's antibiotic susceptibility was highest in Ceftazidime at 92.7%, so Ceftazidime was the most effective antibiotic used to treat infections caused by Burkholderia cepacia. Keywords: antibiotic, Burkholderia cepacia, clinical specimens, distribution