Electronic Theses and Dissertation

ABSTRAK

Proteus mirabilis merupakan bakteri patogen Gram negatif dari famili Enterobacteriaceae yang dapat menyebabkan berbagai penyakit infeksi. Penelitian ini bertujuan untuk mengetahui prevalensi, distribusi berdasarkan usia dan jenis kelamin, jenis spesimen dan ruang rawat pasien serta mengetahui pola kepekaan antibiotik Proteus mirabilis. Penelitian ini menggunakan metode deskriptif yaitu dengan melakukan isolasi, identifikasi dan uji kepekaan antibiotik terhadap Proteus mirabilis yang diisolasi dari spesimen klinis RSUD dr. Zainoel Abidin Banda Aceh. Hasil penelitian ini menunjukkan Proteus mirabilis yang diperoleh dari spesimen klinis periode Maret 2020-Maret 2022 adalah sebanyak 121 isolat. Distribusi Proteus mirabilis berdasarkan jenis spesimen paling banyak ditemukan pada spesimen pus 102 isolat (84,29%). Distribusi Proteus mirabilis berdasarkan usia paling banyak ditemukan pada pasien berusia 46-55 tahun sebanyak 37 isolat (30,57%), sedangkan berdasarkan jenis kelamin paling banyak ditemukan pada pria sebanyak 86 isolat (71,07%). Distribusi Proteus mirabilis berdasarkan jenis ruang rawat paling banyak ditemukan pada ruang operasi dan ruang rawat bedah sebanyak 43 isolat (35,53%). Kepekaan antibiotik Proteus mirabilis paling tinggi pada Cefoperazone sebesar 97,5%, Piperacillin tazobactam sebesar 97,5% dan Amikacin sebesar 96,66%.

Kata Kunci : antibiotik, distribusi, Proteus mirabilis, spesimen klinis

ABSTRACT Proteus mirabilis is a Gram-negatif bacterium from the Enterobacteriaceae family causing various infections. This study aimed to determine the prevalence, the distribution based on patients’ age and sex, type of specimen and patient ward and to determine the pattern of antibiotic sensitivity of Proteus mirabilis. This study used a descriptive method, namely by isolating, identifying and testing antibiotic susceptibility to Proteus mirabilis isolated from clinical specimens of RSUD dr. Zainoel Abidin Banda Aceh. The results of this study showed that there were 121 isolates of Proteus mirabilis obtained from clinical specimens during March 2020-March 2022. The distribution of Proteus mirabilis based on the type of specimen was most predominantly found in pus specimens with 102 isolates (84.29%). The distribution of Proteus mirabilis based on age was most commonly found at patients aged 46-55 years 37 (30.57%), while based on gender, it was most commonly found in men with 86 isolates (71.07%). The distribution of Proteus mirabilis based on the type of ward was mostly found in the operating room and post surgery ward with 43 isolates (35.53%). The susceptibility of Proteus mirabilis to antibiotics was highest to Cefoperazone reaching 97.5%, Piperacillin tazobactam reaching 97.5% and Amikacin reaching 96.66%. Keywords: antibiotic, distribution, Proteus mirabilis, clinical specimens